目的 探讨急性脑梗死患者使用血塞通注射液联合复方脑肽节苷脂注射液治疗的临床疗效。方法 选取2021年1月—2022年12月于太和县人民医院确诊并接受治疗的96例急性脑梗死患者，利用计算机生成的随机数字将入选患者随机分为对照组（n＝48）和治疗组（n＝48）。对照组静脉滴注复方脑肽节苷脂注射液，10mL/次，用250 mL 0.9%氯化钠注射液稀释，1次/d。治疗组在对照组基础上静脉滴注血塞通注射液，400 mg/次，用500 mL 10%葡萄糖注射液稀释，1次/d。比较两组患者治疗14 d的临床疗效、神经功能、血液流变学指标、血清神经营养因子。结果 与对照组总有效率（79.17%）对比，治疗组的总有效率（93.75%）明显更高（P＜0.05）。与治疗前对比，两组美国国立卫生研究院卒中量表（NIHSS）评分显著降低（P＜0.05），并以治疗组NIHSS评分降低更显著（P＜0.05）。与治疗前对比，两组全血高切黏度、全血低切黏度、血浆黏度均呈下降趋势（P＜0.05），且治疗组血液流变学指标下降更显著（P＜0.05）。与治疗前对比，两组患者血清神经生长因子（NGF）、脑源性神经营养因子（BDNF）水平均呈上升趋势（P＜0.05，且治疗组血清NGF、BDNF水平上升更显著（P＜0.05）。结论 急性脑梗死患者在复方脑肽节苷脂注射液基础上加用血塞通注射液的治疗疗效显著，可促进神经功能恢复，改善血液流变学，提高神经营养因子水平。

Objective To explore clinical efficacy of Xuesaitong Injection combined with Compound Brain Peptide Ganglioside Injection in treatment of acute cerebral infarction. Methods A total of 96 patients with acute cerebral infarction who were diagnosed and treated in Taihe County People’s Hospital from January 2021 to December 2022 were selected and randomly divided into control (48 cases) and treatment groups (48 cases) according to computer-generated random numbers. The control group were iv administered with Compound Porcine Cerebroside and Ganglioside Injection, 10 mL/dose, diluted with 250 mL 0.9% sodium chloride injection, once daily. The treatment group were iv administered with Xuesaitong Injection 400 mg/dose based on the control group, diluted with 500 mL of 10% glucose injection, once daily. The clinical efficacy for 14 d, the neurological function, hemorheological indicators, and serum neurotrophic factors in two groups were compared in both group. Results Compared with the total effective rate (79.17%) of the control group, the total effective rate (93.75%) of the treatment group was significantly higher (P < 0.05). Compared with before treatment, NIHSS scores of the two groups showed significant downward trend (P < 0.05), and the decrease of NIHSS scores of the treatment group were significantly lower (P < 0.05). Compared with before treatment, the whole blood high shear viscosity, whole blood low shear viscosity, and plasma viscosity of the two groups significantly decreased (P < 0.05), and the hemorheological indicators in the treatment group were lower than those in the control group (P < 0.05). Compared with before treatment, NGF and BDNF serum levels in two groups showed an upward trend (P < 0.05), and the increase of the serum levels of NGF and BDNF in the treatment group were more significant (P< 0.05). Conclusion On the basis of Compound Brain Peptide Ganglioside Injection, Xuesaitong Injection is effective in treatment of patients with acute cerebral infarction, which can effectively improve hemorheology, increase the level of neurotrophic factors, and promote the recovery of neurological function.

R971

阜阳市自筹类科技计划项目（FK202081085）