活性多肽是美洲大蠊中主要的药用成分，具有广泛的药理活性。近年来，相关领域的学者陆续发现了来源于美洲大蠊的单组分活性多肽，如periplanetasin-2、periplanetasin-4、美洲大蠊防御素（PaDefensins）、periplanetasin-5、Pa-THY1、短神经肽（sNPF）。对美洲大蠊多肽的抗微生物作用、抗肿瘤作用、促伤口愈合作用和神经调节作用进行了综述，以期为美洲大蠊多肽类药物的筛选、结构改造以及新药开发提供参考。

Active peptides are the main medicinal components in Periplaneta americana, and have extensive pharmacological activity. In recent years, scholars in related fields have successively discovered single-component active peptides derived from P. americana, such as periplanetasin-2, periplanetasin-4, PaDefensins, periplanetasin-5, Pa-THY1, and short neuropeptide F (sNPF). This article reviews the antimicrobial effect, anti-tumor effect, wound healing promotion, and neuromodulatory effect of P. americana peptides, in order to provide reference for the screening, structural modification, and new drug development of P. americana peptide drugs.

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国家自然科学基金面上项目(62276191);国家自然科学基金青年项目(31700086)