[关键词]
[摘要]
目的 探讨前列舒乐颗粒联合非那雄胺片治疗良性前列腺增生症的临床疗效。方法 选取2021年1月—2022年12月如皋市人民医院收治的100例良性前列腺增生症患者,根据随机数字表法将所有患者分为对照组和治疗组,每组各50例。对照组口服非那雄胺片,1片/次,1次/d。治疗组在对照组基础上口服前列舒乐颗粒,1袋/次,3次/d。两组治疗12周后统计疗效。观察两组的临床疗效,比较两组的临床体征、临床症状、尿动力学、前列腺液炎症因子水平。结果 治疗后,治疗组、对照组的总有效率为88.00%、72.00%,组间的差异显著(P<0.05)。治疗后,两组的前列腺体积(PV)、膀胱残余尿量(RUV)低于治疗前,最大尿流率(Qmax)高于治疗前(P<0.05);治疗组患者的PV、RUV低于对照组,Qmax高于对照组(P<0.05)。治疗后,两组的国际前列腺症状评分(IPSS)评分显著降低(P<0.05),治疗组较对照组IPSS评分降低更明显(P<0.05)。治疗后,两组的最大尿道闭合压、最大尿道压高低于治疗前(P<0.05),且治疗组最大尿道闭合压、最大尿道压比对照组低(P<0.05)。治疗后,两组前列腺液白细胞介素-8(IL-8)、前列腺特异性抗原(PSA)低于治疗前(P<0.05);治疗组的前列腺液IL-8、PSA低于对照组(P<0.05)。结论 前列舒乐颗粒联合非那雄胺片可提高良性前列腺增生症的疗效,显著缩小前列腺体积和减轻临床症状,改善尿动力学水平,降低炎症反应。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Qianlie Shule Granules combined with Finasteride Tablets in treatment of benign prostatic hyperplasia. Methods Patients (100 cases) with benign prostatic hyperplasia in the People’s Hospital of Rugao from January 2021 to December 2022 were divided into control and treatment groups according to the random number table method, and each group had 50 cases. Patients in the control group were po administered with Finasteride Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Qianlie Shule Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and the clinical signs, symptoms, urodynamics, and levels of inflammatory factors in prostate fluid of two groups were compared. Results After treatment, the total effective rate of the treatment group was 88.00%, while the total effective rate of the control group was 72.00%, with significant differences between the groups (P< 0.05). After treatment, PV and RUV of two groups were lower than before treatment, while Qmax of two groups was higher than that of the control group (P < 0.05). PV and RUV of the treatment group were lower than those of the control group, while Qmax of the treatment group was higher than that of the control group (P < 0.05). After treatment, IPSS scores of two groups were significantly decreased (P < 0.05), and IPSS scores of the treatment group were more significant decrease than that of the control group (P< 0.05). After treatment, the maximum urethral closure pressure and maximum urethral pressure in two groups were lower than before treatment (P < 0.05), and the maximum urethral closure pressure and maximum urethral pressure in the treatment group were lower than those in the control group (P < 0.05). After treatment, the levels of IL-8 and PSA in prostate fluid in two groups were lower than before treatment (P < 0.05). IL-8 and PSA levels in the prostate fluid of the treatment group were lower than those of the control group (P < 0.05). Conclusion Qianlie Shule Granules combined with Finasteride Tablets can improve the curative effect of benign prostatic hyperplasia, significantly reduce prostate volume and alleviate clinical symptoms, improve urodynamic levels, reduce inflammatory reactions.
[中图分类号]
R983
[基金项目]
无锡市科技发展资金项目(N20192004)