目的 观察散风通窍滴丸联合氯雷他定片治疗儿童过敏性鼻炎的临床疗效。方法 选取2021年12月—2022年11月在茂名市人民医院诊疗的100例肺经伏热型过敏性鼻炎患儿，按照随机数字表法将患儿分为对照组和治疗组，各50例。对照组患儿服用氯雷他定片，1次/d，12岁以上和体质量＞30 kg，1片/次；12岁及以下和体质量≤30 kg，0.5片/次。治疗组患儿在对照组基础上口服散风通窍滴丸，10丸/次，3次/d。两组患儿均治疗3周。观察两组的临床疗效，比较两组的鼻炎症状、血清免疫因子指标、炎症因子水平。结果 治疗后，治疗组患儿的总有效率为88.00%，明显高于对照组的总有效率80.00%，差异有统计学意义（P＜0.05）。治疗后，两组患儿鼻塞、鼻痒、喷嚏、流涕评分均显著降低（P＜0.05），且治疗后治疗组患儿鼻塞、鼻痒、喷嚏、流涕评分明显低于对照组，差异有统计学意义（P＜0.05）。治疗后，两组患儿血清免疫球蛋白（Ig）A、IgE、IgM水平均显著下降（P＜0.05），且治疗组的血清IgA、IgE、IgM水平均低于对照组，差异具有统计学意义（P＜0.05）。两组患儿血清白细胞介素（IL）-4、IL-6、肿瘤坏死因子-α（TNF-α）水平均显著下降，IL-10水平升高（P＜0.05），且治疗组的血清IL-4、IL-6、TNF-α水平均低于对照组，IL-10水平高于对照组，差异具有统计学意义（P＜0.05）。结论 散风通窍滴丸联合氯雷他定片治疗儿童过敏性鼻炎疗效显著，可改善临床症状，降低免疫因子指标，改善全身炎症反应。

Objective To observe the effectiveness of Sanfeng Tongjiao Pills combined with Loratadine Tablets in treatment of allergic rhinitis in children. Methods Children (100 cases) with allergic rhinitis in Maoming People’s Hospital from December 2021 to November 2022 were divided into control and treatment groups according to the random number table method, and each group had 50 cases. Children in the control group were po administered with Loratadine Tablets, once daily, over 12 years old and with a body mass greater than 30 kg, 1 tablet/time; 12 years old and below, with a body mass ≤ 30 kg, 0.5 tablet/time. Children in the treatment group were po administered with Sanfeng Tongjiao Pills on the basis of the control group, 10 pills/time, three times daily. Children in two groups were treated for 3 weeks. After treatment, the clinical efficacies were evaluated, and rhinitis symptom, serum immune factor indicators, and the levels of inflammatory factors in two groups were compared. Results After treatment, the total effective rate of children in the treatment group was 88.00%, significantly higher than 80.00% in the control group, with a statistically significant difference (P< 0.05). After treatment, the scores of nasal congestion, itching, sneezing, and runny nose in two groups were significantly decreased (P < 0.05), and the scores of nasal congestion, itching, sneezing, and runny nose in the treatment group were significantly lower than those in the control group, with a statistically significant difference (P< 0.05). After treatment, the serum levels of IgA, IgE, and IgM in two groups of patients were significantly decreased (P < 0.05), and the serum levels of IgA, IgE, and IgM in the treatment group were lower than those in the control group, with statistical significance (P < 0.05). The serum levels of IL-4, IL-6, and TNF-α in two groups were significantly decreased, while the serum levels of IL-10 in two groups were increased (P < 0.05). The serum levels of IL-4, IL-6, and TNF-α in the treatment group were lower than those in the control group, but the serum levels of IL-10 in the treatment group were higher than those in the control group, with statistical significance (P< 0.05). Conclusion Sanfeng Tongjiao Pills combined with Loratadine Tablets has better efficacy in treatment of allergic rhinitis in children, can improve clinical symptoms, reduce immune factor indicators, and improve systemic inflammatory response.

R985；R987