目的 探讨脉络宁注射液联合己酮可可碱注射液治疗急性脑梗死的临床疗效。方法 选取2019年1月—2022年10月太和县人民医院收治的84例急性脑梗死患者，根据随机数字表法将84例患者分为对照组和治疗组，每组各42例。对照组静脉滴注己酮可可碱注射液，于250 mL生理盐水中加入0.1 g己酮可可碱注射液，最大滴速＜0.1 g/h，依据患者耐受性每次增加0.05 g，每次用药量不超过0.2 g。治疗组患者在对照组治疗的基础上静脉滴注脉络宁注射液，于250 mL 0.9%氯化钠注射液中加入20 mL脉络宁注射液，1次/d。两组患者均连续治疗10 d。观察两组的临床疗效，比较两组治疗前后神经功能、凝血功能指标、血清炎症因子。结果 治疗后，治疗组总有效率95.24%高于对照组的总有效率80.95%，差异有统计学意义（P＜0.05）。治疗后，两组美国国立卫生研究院卒中量表（NIHSS）评分下降（P＜0.05），且治疗组NIHSS评分低于对照组（P＜0.05）。治疗后，两组纤维蛋白原（FIB）均下降，凝血酶时间（TT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）均升高（P＜0.05），且治疗组FIB低于对照组，TT、PT、APTT均高于对照组，差异有统计学意义（P＜0.05）。治疗后，两组血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）水平均显著下降（P＜0.05），且治疗组血清IL-6、TNF-α、CRP水平均低于对照组，差异有统计学意义（P＜0.05）。结论 脉络宁注射液联合己酮可可碱注射液治疗急性脑梗死的效果显著，可有效改善患者神经功能和凝血功能、降低炎症反应。

Objective To explore the clinical effect of Mailuoning Injection combined with Pentoxifylline Injection in treatment of cerebral infarction. Methods Patients (84 cases) with cerebral infarction in Taihe County People’s Hospital from January 2019 to October 2022 were divided into control and treatment groups according to the random number table method, and each group had 42 cases. Patients in the control group were iv administered with Pentoxifylline Injection, 0.1 g added into normal saline 250 mL, drip rate of < 0.1 g/h, according to the patient’s tolerance, increasing the dosage by 0.05 g each time, and the dosage should not exceed 0.2 g each time. Patients in the treatment group were iv administered with Mailuoning Injection on the basis of the control group, 20 mL added into 0.9% sodium chloride injection, once daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and the nerve function, coagulation function index, serum inflammatory factor in two groups were compared. Results After treatment, the total effective rate of 95.24% in the treatment group was higher than 80.95% in the control group, with a statistically significant difference (P < 0.05). After treatment, NIHSS scores of two groups were decreased (P < 0.05), and NIHSS scores of the treatment group were lower than those of the control group (P < 0.05). After treatment, FIB in two groups were decreased, but TT, PT, and APTT in two groups were increased (P < 0.05). FIB in the treatment group was lower than that in the control group, while TT, PT, and APTT were higher than those in the control group, with a statistically significant difference (P < 0.05). After treatment, the serum levels of IL-6, TNF-α, and CRP in two groups were significantly decreased (P < 0.05), and the serum levels of IL-6, TNF-α, and CRP in the treatment group were lower than those in the control group, with statistical significance (P < 0.05). Conclusion Mailuoning Injection combined with Pentoxifylline Injection has a significant effect in treatment of cerebral infarction, can effectively improve the neurological function and coagulation function of patients, reduce inflammatory response.

R971

阜阳市自筹类科技计划项目(FK202081085)