2型糖尿病"多食易饥"现象控制难度大，大量进食进一步促进病情进展。饥饿素是空腹时由胃底细胞分泌的一种食欲调节激素，是目前已知的唯一与食欲直接相关的激素。饥饿素作为与食欲密切相关的激素，二甲双胍、噻唑烷二酮类药物、α-葡萄糖苷酶抑制剂、二肽基肽酶-4（DPP-4）抑制剂、胰高血糖素样肽-1（GLP-1）类似物、钠-葡萄糖共转运蛋白2（SGLT-2）抑制剂等2型糖尿病治疗药物均对其水平产生一定的影响。综述了各类常见2型糖尿病治疗药物对血浆饥饿素水平的影响，为以饥饿素作为靶点的2型糖尿病的防治研究提供新思路。

It is difficult to control the phenomenon of "overeating and easy hunger" in type 2 diabetes. Eating in large quantities further promotes the progress of the disease. Ghrelin is an appetite-related hormone secreted by gastric fundus cells under fasting state, and it is the only known hormone directly related to appetite. As a hormone closely related to appetite, the level of ghrelin could be affected by type 2 diabetes drugs, such as metformin, thiazolidinediones, α-glycosidase inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like petide-1 (GLP-1) analogues, and sodium-glucose cotransporter-2 (SGLT-2) inhibitors. This article reviews the effects of various common therapeutic drugs for type 2 diabetes on plasma ghrelin levels, so as to provide new ideas for the prevention and treatment of type 2 diabetes with ghrelin as a target.

R965

国家自然科学基金资助项目（81904082）