目的 探讨女珍颗粒联合艾司唑仑治疗肝肾阴虚型更年期失眠症的临床疗效。方法 选取2022年1月-2022年12月张家口市第四医院收治的130例肝肾阴虚型更年期失眠症患者，随机分为对照组和治疗组，每组各65例。对照组口服艾司唑仑片，2 mg/次，3次/d。治疗组在此基础上口服女珍颗粒，6 g/次，3次/d。两组患者均持续治疗4周。观察两组患者临床疗效，比较治疗前后两组患者睡眠状况，神经递质β-内啡肽（β-EP）、5-羟色胺（5-HT）水平。结果 治疗后，治疗组患者总有效率较对照组显著升高（98.46%vs 89.23%，P<0.05）。治疗后，两组患者睡眠效率（SE）明显高于治疗前，而睡眠潜伏期（SL）、觉醒次数（AT）、觉醒时间（AWT）和REW睡眠潜伏期（RL）均明显降低（P<0.05），且治疗组患者睡眠状况明显好于对照组（P<0.05）。治疗后，两组β-EP和5-HT水平较治疗前均明显升高（P<0.05），且治疗组明显高于对照组（P<0.05）。结论 女珍颗粒联合艾司唑仑治疗肝肾阴虚型更年期失眠症疗效和安全性均较高，其不仅能有效提高患者睡眠质量，同时还能改善患者神经递质水平。

Objective To explore the curative effect of Nvzhen Granules combined with estazolam in treatment of menopausal insomnia of yin deficiency of liver and kidney. Methods Patients (130 cases) with menopausal insomnia of yin deficiency of liver and kidney in the NO.4 Hospital of Zhangjiakou from January 2022 to December 2022 were randomly divided into control and treatment group, and each group had 65 cases. Patients in the control group were po administered with Estazolam Tablets, 2 mg/time, three times daily. Patients in the treatment group were po administered with Nvzhen Granules on the basis of the control group, 6 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluation was evaluated, and the sleep status, the levels β-EP and 5-HT in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group (98.46% vs 89.23%, P < 0.05). After treatment, SE in both groups was significantly higher than that before treatment, while SL, AT, AWT, and RL were significantly decreased in both groups (P < 0.05), and the sleep status of patients in the treatment group was significantly better than that in the control group (P< 0.05). After treatment, the levels of β-EP and 5-HT in two groups were significantly higher than those before treatment, and which in the treatment group were significantly higher than those in the control group (P < 0.05). Conclusion Nvzhen Granules combined with estazolam has high efficacy and safety in treatment of menopausal insomnia of yin deficiency of liver and kidney, which can not only effectively improve the sleep quality of patients, but also improve the level of neurotransmitters.

R971

张家口市重点研发计划项目（2221171D）