感染性肺炎已成为重大的全球健康问题,抗感染是临床治疗感染性肺炎最主要的治疗方式。黄芩素是黄芩中的黄酮类成分,具有多种活性,可减轻病原微生物感染介导的炎症反应,抑制多种炎症因子的分泌,直接抗病毒和协同抗病毒作用,抗细胞凋亡,促进肺上皮细胞修复减轻肺部病理损伤。总结了黄芩素防治感染性肺炎的作用机制,为指导黄芩素的临床使用提供参考。

Infectious pneumonia has become a major global health issue, and anti-infection is the most important treatment for infectious pneumonia in clinical practice. Baicalin is a flavonoid component from Scutellariae Radix, which has various activities. Baicalin can reduce the inflammatory reaction mediated by pathogenic microorganism infection, inhibit the secretion of various inflammatory factors, directly and cooperatively antiviral effect, anti-apoptosis, promote the repair of pulmonary epithelial cells and reduce pathological damage to the lungs. This article summarized the mechanism of baicalin in prevention and treatment of infectious pneumonia, providing a reference for guiding the clinical use of baicalin.

R974

重庆市科卫联合医学科研项目(2019ZDXM042)