疱疹病毒感染类疾病高发,可形成终生感染,给人类健康和财产安全带来了极大的损失。然而,临床上批准常用的治疗疱疹病毒感染的药物仅几种核苷类似物,这些药物的应用往往还会引发耐药性和不良反应。因而,克服抗疱疹病毒药物存在的问题,探索新型的抗疱疹病毒药物迫在眉睫。总结了临床常用抗疱疹病毒感染药物、靶向病原体的抗疱疹病毒抑制剂和靶向宿主的抗疱疹病毒抑制剂,介绍了联合用药抗病毒新型策略,以期为科研人员在抗疱疹病毒药物方面的研究提供参考。

The high incidence of herpesvirus infection can lead to life-long infection, which brings great loss to human health and property safety. Only few nucleoside analog drugs are approved for the treatment of herpesvirus infections, and long-term use of these drugs often leads to drug resistance and adverse action. Overcoming the problems of anti-herpesvirus drugs and exploring new types of anti-herpesvirus drugs is urgent. This article summarizes commonly used anti-herpesvirus infection drugs in clinical practice, anti-herpesvirus inhibitors targeting pathogens, anti-herpesvirus inhibitors targeting hosts, and new strategies for combination therapy of antiviral drugs, hoping to provide reference for researchers in the research of anti-herpesvirus drugs.

R978.7