目的 探探讨滋补生发片联合米诺地尔搽剂治疗男性雄激素性脱发的临床疗效。方法 选取2020年1月-2021年6月在西宁市第一人民医院整形美容科就诊的100例男性雄激素性脱发患者,按照随机数字表法将所有患者分为对照组和治疗组,每组各50例。对照组外涂米诺地尔搽剂,1 mL/次,2次/d。治疗组患者在对照组治疗的基础上口服滋补生发片,6~8片/次,3次/d。4周为1个疗程,两组共治疗6个疗程。观察两组的临床疗效,比较两组的脱发、瘙痒、油腻、鳞屑中医证候积分和毛发生长情况。结果 治疗后,治疗组总有效率为94%,对照组总有效率76%,治疗组疗效优于对照组(P<0.05)。治疗后,两组患者脱发、瘙痒、油腻、鳞屑积分均显著降低(P<0.05);且治疗组脱发、瘙痒、油腻、鳞屑积分较对照组各项积分也明显降低(P<0.05)。治疗后,治疗组的毛发生长速度、生长长度较对照组明显升高(P<0.05)。结论 滋补生发片联合米诺地尔搽剂治疗男性雄激素性脱发疗效更好,可改善脱发、瘙痒、油腻、鳞屑症状,促进毛发生长。

Objective To investigation of the clinical efficacy of Zibu Shengfa Tablets combined with Minoxidil Liniment in treatment of male androgenetic alopecia. Methods Male patients (100 cases) with androgenetic alopecia in Xining First People's Hospital from January 2020 to June 2021 were divided into control and treatment groups according to the random number table method, and each group had 50 cases. Patients in the control group were externally applied with Minoxidil liniment, 1 mL/time, twice daily. Patients in the treatment group were po administered with Zibu Shengfa Tablets on the basis of the control group, 6-8 tablets/time, three times daily. Four weeks is a course of treatment, and patients in two groups were treated for 6 courses. After treatment, the clinical efficacies were evaluated, and traditional Chinese medicine syndrome scores of hair loss, itching, greasy, and scaling, and the hair growth status in two groups were compared. Results After treatment, total effective rate of the treatment group was 94%, while the total effective rate of the control group was 76%, and the therapeutic effect of the treatment group washigher than that of the control group (P < 0.05). After treatment, the scores of hair loss, itching, greasiness, and scales in two groups were significantly reduced (P < 0.05). Moreover, the scores for hair loss, itching, oiliness, and scales in the treatment group had significantly lower compared to the control group (P < 0.05). After treatment, the hair growth rate and length of the treatment group were significantly increased compared to the control group (P < 0.05). Conclusion Zibu Shengfa Tablets combined with Minoxidil Liniment has clinical effect in treatment of male androgenetic alopecia, can improve symptoms of hair loss, itching, greasy, and scaling, promote hair growth.

R986