目的 探讨一清胶囊联合卤米松乳膏治疗寻常型银屑病的临床疗效。方法 选择2020年9月-2022年9月东南大学附属中大医院江北院区接诊的128例寻常型银屑病患者,随机分为对照组和治疗组,每组各64例。对照组患者于患处薄层涂搽卤米松乳膏,2次/d。治疗组在对照组的基础上口服一清胶囊,3次/d,2粒/次。两组患者均给予6周治疗。观察两组患者临床疗效,比较治疗前后两组患者严重程度指数(PASI)评分,临床症状评分,血清白细胞介素-17(IL-17)和肿瘤坏死因子-α(TNF-α)水平。结果 治疗后,治疗组临床总有效率为98.44%,明显高于对照组(87.50%,P<0.05)。治疗后,两组PASI评分和临床症状评分显著下降(P<0.05),并且治疗组下降更显著(P<0.05)。治疗后,两组血清IL-17和TNF-α水平显著降低(P<0.05),并且治疗组降低更明显(P<0.05)。结论 一清胶囊联合卤米松乳膏治疗寻常型银屑病的效果确切,能有效缓解皮损严重程度,改善患者的临床症状,以及抑制炎症反应。

Objective To investigate the efficacy of Yiqing Capsules combined with Halometasone Cream in treatment of psoriasis vulgaris. Methods Patients (128 cases) with psoriasis vulgaris in Zhongda Hospital Southeast University (Jiangbei) from September 2020 to September 2022 were randomly divided into control and treatment group, and each group had 64 cases. Patients in the control group were administered with Halometasone Cream to the affected area, twice daily. Patients in the treatment group were po administered with Yiqing Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical evaluation was evaluated, and the scores of PASI and clinical symptoms, the serum levels of IL-17 and TNF-α in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 98.44%, which was significantly higher than that of the control group (87.50%, P < 0.05). After treatment, the PASI score and clinical symptom score in two groups were significantly decreased (P < 0.05), especially in the treatment group (P < 0.05). After treatment, the levels of serum IL-17 and TNF-α in two groups were significantly decreased (P < 0.05), especially in the treatment group (P < 0.05). Conclusion Yiqing Capsules combined with Halomethasone Cream is effective in treatment of psoriasis vulgaris, which can effectively alleviate the severity of skin lesions, improve clinical symptoms and inhibit inflammatory reaction.

R986

江苏省“六大人才高峰”高层次人才选拔培养资助项目(WSW-031)