妊娠期糖尿病是糖尿病中的特殊类型，寻找疗效确切、作用多样的治疗药物成为临床研究的热点。葛根素是由葛根中提取的活性成分，已被证明可以预防各种病理生理过程，包括糖尿病及其并发症等。葛根素可以通过降低胰岛素抵抗，降低细胞凋亡、保护胰岛素β细胞功能，增强机体抗氧化活性，提升降糖效果而发挥降糖作用。探讨了葛根素防治妊娠糖尿病的作用机制，为指导妊娠糖尿病的临床治疗提供参考。

Gestational diabetes mellitus is a special type of diabetes, and finding effective and multi acting therapeutic drugs has become a hot topic in clinical research. Puerarin is an active ingredient extracted from Puerariae Lobatae Radix, which has been proved to prevent various pathophysiological processes, including diabetes and its complications. Puerarin can reduce insulin resistance, reduce cell apoptosis and protect the function of insulin β cells, enhancing the body's antioxidant activity, and improve the hypoglycemic effect. This article discusses the mechanism of puerarin in prevention and treatment of gestational diabetes mellitus, and provides a reference for guiding the clinical treatment of gestational diabetes mellitus.

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廊坊市科技支撑计划项目（2020013069）