骨关节炎是一种全球常见的炎症性疾病，目前临床治疗骨关节炎的方法以缓解骨关节炎疼痛、抑制炎症的对症治疗方案为主。漆黄素属于黄酮类物质，具有多种生理活性，可以促进衰老细胞凋亡，抑制血管新生，阻断软骨下骨与软骨的异常串扰，调节炎性因子，保护软骨细胞免受氧化应激。综述了漆黄素治疗骨关节炎的作用机制，为深入开展漆黄素治疗骨关节炎的基础研究以及新型药物的开发提供依据。

Osteoarthritis is a common inflammatory disease in the world. At present, the clinical treatment of osteoarthritis is mainly symptomatic treatment to alleviate the pain and inflammation of osteoarthritis. Fisetin is a flavonoid substance, which has various physiological activities. Fisetin can promote apoptosis of aging cells, inhibit angiogenesis, block abnormal crosstalk between subchondral bone and cartilage, regulate inflammatory factors, and protect chondrocytes from oxidative stress. This article reviews the mechanism of fisetin in treatment of osteoarthritis, and provides a basis for further basic research on fisetin in treatment of osteoarthritis and the development of new drugs.

R285.5；R982

国家中医药管理局中医药循证能力建设项目（2019XZZX-GK006）；天津市教委科研计划项目（2019KJ064）；天津市名中医传承工作室建设项目（881022）