目的 探讨氟米龙联合曲安奈德治疗治疗过敏性结膜炎的临床疗效。方法 选取2021年7月—2022年10月桂林医学院第二附属医院眼科及贵港爱尔眼科收治的70例过敏性结膜炎患者，随机分为对照组（35例）和治疗组（35例）。对照组患者给予氟米龙滴眼液，2滴/次，3次/d。在对照组的基础上，治疗组结膜下注射曲安奈德注射液，10 mg/0.25 mL，1次/d，共2次。两组患者用药7 d。观察两组患者临床疗效，比较治疗前后两组患者症状好转时间，血清炎性因子P物质（SP）、干扰素-γ（IFN-γ）、白细胞介素-17（IL-17）、胸腺基质淋巴细胞生成素（TSLP）水平及不良反应发生情况。结果 治疗后，治疗组患者总有效率（97.14%）明显高于对照组（80.03%，P＜0.05）。治疗后，治疗组眼睛痒、结膜充血、流泪、结膜囊分泌物增多好转时间均短于对照组（P＜0.05）。治疗后，两组血清炎性因子IL-17、SP、TSLP水平低于治疗前，而IFN-γ水平高于治疗前（P＜0.05），且治疗组这些血清炎性因子水平明显好于对照组（P＜0.05）。结论 氟米龙联合曲安奈德治疗过敏性结膜炎效果确切，能较快好转症状，有效降低炎性因子水平。

Objective To investigate the therapeutic effect of fluorometholone combined with triamcinolone acetonide in treatment of allergic conjunctivitis. Methods Patients (70 cases) with allergic conjunctivitis in the Second Affiliated Hospital Guilin Medical University and Eye Ophthalmology Hospital (Guigang) from Junly 2021 to October 2022 were randomly divided into control (35 cases) and treatment (35 cases) group. Patients in the control group were administered with Fluorometholone Eye Drops, 2 drops/time, three times daily. Patients in the treatment group were subconjunctival injected with Triamcinolone Acetonide Injection on the basis of the control group, 10 mg/0.25 mL, once daily for two times. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, and the improvement time of symptom, the serum IL-17, SP, TSLP, and IFN-γ levels, and complications in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (97.14%) was significantly higher than that of the control group (80.03%, P < 0.05). After treatment, the improvement time of itchy eyes, conjunctival congestion, tears, conjunctival sac secretion increased in the treatment group was earlier than that in the control group (P < 0.05). After treatment, the levels of serum inflammatory factors IL-17, SP and TSLP in two groups were lower than those before treatment, while the level of IFN-γ was significantly increased (P < 0.05), and the level of serum inflammatory factors in the treatment group was significantly better than that in the control group (P < 0.05). Conclusion Triamcinolone acetonide combined with Fluorometholone Eye Drops is effective in treatment of allergic conjunctivitis, which can quickly improve the symptoms and effectively reduce the level of inflammatory factors.

R988.1

广西医疗卫生适宜技术开发与推广应用项目（S2020107）