目的 探讨当归苦参丸联合克林霉素磷酸酯凝胶治疗玫瑰痤疮的临床疗效。方法 选择2019年11月—2022年8月天津市北辰医院收治120例玫瑰痤疮者，随机分为对照组（60例）和治疗组（60例）。对照组患者外涂克林霉素磷酸酯凝胶，2次/d。在对照组的基础上，治疗组口服当归苦参丸，6 g/次，2次/d。两组服药8周。观察两组患者临床疗效，比较治疗前后两组患者症状缓解时间，皮肤病生活质量量表（DLQI），血清炎性因子肿瘤坏死因子-α（TNF-α）、抗菌肽-37（LL-37）、白细胞介素-6（IL-6）和干扰素-γ（INF-γ）水平及不良反应情况。结果 治疗后，治疗组患者临床有效率为98.33%，明显高于对照组（83.33%，P＜0.05）。治疗后，治疗组患者症状缓解时间均早于对照组（P＜0.05）。治疗后，两组患者DLQI评分均明显下降（P＜0.05），且治疗组的DLQI评分低于对照组（P＜0.05）。治疗后，两组患者LL-37、IL-6、TNF-α水平均低于治疗前，而IFN-γ水平高于治疗前（P＜0.05），且治疗组血清炎性因子水平明显好于对照组（P＜0.05）。治疗后，治疗组不良反应发生率（5.00%）明显低于对照组（11.67%，P＜0.05）。结论 当归苦参丸联合克林霉素磷酸酯凝胶治疗玫瑰痤疮效果确切，可显著改善症状，有效降低炎性反应。

Objective To observe the clinical efficacy of Danggui Kushen Pills combined with Clindamycin Phosphate Gel in treatment of rosacea. Methods Patients (120 cases) with rosacea in Tianjin Beichen Hospital from November 2019 to August 2022 were randomly divided into control (60 cases) and treatment (60 cases) group. Patients in the control group were coated with Clindamycin Phosphate Gel, twice daily. Patients in the treatment group were po administered with Danggui Kushen Pills on the basis of the control group, 6 g/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, and the relief time of symptom, scoring ratio of dermatosis quality of life, serum inflammatory factor LL-37, IL-6, TNF-α and IFN-γ levels, and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 98.33%, which was significantly higher than that of the control group (83.33%, P < 0.05). After treatment, the time of symptom relief in the treatment group was earlier than that in the control group (P < 0.05). After treatment, the DLQI score in two groups were significantly decreased (P < 0.05), and the DLQI score of the treatment group was lower than that of the control group (P < 0.05). After treatment, the levels of LL-37, IL-6 and TNF-α in two groups were lower than those before treatment, while the level of IFN-γ was higher (P < 0.05), and the level of serum inflammatory factors in the treatment group was significantly better than that in the control group (P < 0.05). After treatment, the incidence of adverse reactions in the treatment group (5.00%) was significantly lower than that in the control group (11.67%, P < 0.05). Conclusion Clindamycin Phosphate Gel combined with Danggui Kushen Pills is effective in treatment of roseacne, which can significantly improve the symptoms and effectively reduce the inflammatory reaction.

R986