目的 建立离子色谱–抑制电导法同时测定硫酸镁钠钾口服用浓溶液中镁、钠、钾离子的方法。方法 采用Dionex IonPac^TM CS12A色谱柱（250 mm×4 mm），Dionex IonPac^TM CG12A保护柱（50 mm×4 mm）；以甲烷磺酸溶液为洗脱液，梯度洗脱，体积流量为1.0 mL/min，柱温30 ℃，检测池温度35 ℃，电导检测器，抑制器为Dionex CDRS 600 4 mm，电流值117 mA，进样体积为25 μL。结果 镁在0.72～1.08μg/mL、钠在12.80～19.20 μg/mL、钾在3.20～4.80 μg/mL线性关系良好，平均回收率分别为101.0%、100.7%、102.9%，RSD值分别为1.4%、1.4%、0.7%。结论 该方法简单、快速、准确，能够有效地控制硫酸镁钠钾口服用浓溶液中镁、钠、钾离子。

Objective To establish method for simultaneous determination of magnesium, sodium, potassium ions in Magnesium Sulfate, Sodium Sulfate and Potassium Sulfate concentrate Oral Solution by ion chromatography-suppressed conductivity (IC-CD). Methods The assay was performed on an Dionex IonPac^TM CS12A (250 mm×4 mm) and guard column Dionex IonPac^TM CG12A (50 mm×4 mm). Methane sulfonic acid solution was used as eluent by gradient elution. Flow rate was 1.0 mL/min, and column temperature was 30℃. Detection cell temperature was set at 35℃, conductivity detector was used, and suppressor conductivity detector was Dionex CDRS 600 4 mm. Current value was 117 mA, and injection volume was 25 μL. Results There was good linear relationship between magnesium at 0.72-1.08 μg/mL, sodium at 12.80-19.20 μg/mL, and potassium at 3.20-4.80 μg/mL. Their average recoveries were 101.0%, 100.7%, and 102.9%, with RSD values of 1.4%, 1.4%, and 0.7%, respectively. Conclusion The method is simple, fast, and accurate, and can effectively control magnesium, sodium, potassium ions in Magnesium Sulfate, Sodium Sulfate and Potassium Sulfate concentrate Oral Solution.

R927.1