糖尿病是全球最大的公共卫生问题之一。二甲双胍是糖尿病临床治疗的一线用药，却无法避免患者出现药物不良反应。二甲双胍具有乳酸性酸中毒、胃肠道不良反应、厌食、神经系统的负面影响、维生素B12缺乏症以及其他不良反应。因此就二甲双胍在糖尿病治疗中的各种不良反应及其分子机制进行综述，以期为二甲双胍的临床使用提供一定的指导作用。

Diabetes is one of the biggest public health problems in the world. Metformin is the first-line drug for clinical treatment of diabetes, but it cannot avoid adverse drug reactions in patients. Metformin has various adverse reactions, such as lactic acid acidosis, gastrointestinal adverse reactions, anorexia, negative effects on the nervous system, vitamin B12 deficiency, and other adverse reactions. Therefore, this article reviews the adverse reactions of metformin in treatment of diabetes and their molecular mechanisms, with a view to guiding the clinical use of metformin.

R977

江苏省第二批中医药领军人才项目（SLJ0225）