骨折是威胁人类身体健康的重要疾病之一，骨折愈合除了与骨折本身的损伤程度有关以外，还与骨折端血液循环、内分泌、骨吸收/骨形成平衡、雌激素等因素有关。柚皮苷是骨碎补中活性成分，是一种二氢类黄酮化合物，具有多种药理活性，能够促进成骨细胞增殖和分化，促进新生血管形成，增强雌激素受体α的活性，促进骨保护素的分泌，抑制核因子-κB信号通路激活，激活Ras信号通路，形成复合材料，通过多种机制或途径促进骨折愈合。综述了柚皮苷促进骨折愈合的作用机制研究进展，希望为柚皮苷的临床使用提供参考。

Fracture is one of the important diseases threatening human health. Fracture healing is not only related to the degree of injury of the fracture itself, but also related to blood circulation at the fracture end, endocrine, bone absorption/bone formation balance, estrogen, and other factors. Naringin is an effective component in Drynariae Rhizoma, and it is a dihydroflavonoid compound with a variety of pharmacological activities. Naringin can promote the proliferation and differentiation of osteoblasts, promote neovascularization, enhance the activity of estrogen receptor α, promote the secretion of osteoprotegerin, inhibit the activation of NF-κB signaling pathway, activate Ras signaling pathway, and form composite materials to promote fracture healing through a variety of mechanisms or pathways. This article reviews the research progress on naringin in promoting fracture healing, hoping to provide reference for the clinical use of naringin.

R966

山东省中医药科技发展计划项目（2017-429）