血管生成是恶性肿瘤的标志之一，涉及血管内皮细胞的增殖、迁移和细胞外基质分解等多种途径。血管内皮生长因子（VEGF）靶向抗肿瘤血管生成是临床肿瘤治疗的有效方法。木犀草素为黄酮类化合物，具有抗肿瘤活性，可通过抑制VEGF及相关信号通路、抑制磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/Akt）信号通路、抑制血管新生分子、抑制孕激素活性、靶向刺激Wnt信号通路、阻断生长停滞特异性蛋白6（Gas6）/受体酪氨酸激酶（Axl）信号通路而发挥抗肿瘤的血管生成作用。归纳了木犀草素抗肿瘤血管生成的作用机制，以期为木犀草素的临床应用提供参考。

Angiogenesis is one of the hallmarks of malignant tumors, which involves the proliferation, migration, and extracellular matrix decomposition of vascular endothelial cells. Targeted anti-angiogenesis of vascular endothelial growth factor (VEGF) is an effective method for clinical tumor treatment. Luteolin is a flavonoid compound with various anti-tumor activities. Luteolin plays an anti-tumor angiogenesis role by inhibiting VEGF and related signal pathways, PI3K/Akt signal pathway, inhibiting angiogenesis molecules, inhibiting progesterone activity, targeting the stimulation of Wnt signal pathway, blocking Gas6/Axl signal pathway. This paper summarizes the anti-tumor angiogenesis mechanism of luteolin in order to provide reference for clinical application of luteolin.

R966

河北省中医药管理局科研计划项目（2018014）