恶性肿瘤的治疗一直是一项医学难题，在过去的半个世纪中，肿瘤发病率和死亡率不断增加，持续危害着人类的生命健康。从木香中提取出来的木香烃内酯是一种天然倍半萜烯内酯，具有较强的抗肿瘤作用，可抑制肿瘤细胞增殖，诱导肿瘤细胞凋亡，抑制肿瘤细胞迁移和侵袭，可多药耐药性逆转和协同用药。对木香烃内酯的抗肿瘤作用机制进行综述，以期对其进一步的临床研究和应用提供参考。

The treatment of malignant tumors has always been a medical problem. In the past half century, the incidence and mortality of tumors have been increasing, which continues to endanger human life and health. Costunolide extracted from Aucklandiae Radix is a natural sesquiterpene lactone with strong anti-tumor effect. Costunolide can inhibit tumor cell proliferation, induce tumor cell apoptosis, inhibit tumor cell migration and invasion, and can reverse multidrug resistance and cooperate with drugs. This article reviews the anti-tumor mechanism of costunolide to provide reference for its further clinical research and application.

R966

国家自然科学基金资助项目（81402344）；陕西省自然科学基础研究计划项目（2020JM-595）