目的 探讨香菊胶囊联合盐酸西替利嗪滴剂治疗儿童过敏性鼻炎的临床疗效。方法 选取2020年9月—2022年3月在无锡市新吴区新瑞医院就诊的122例过敏性鼻炎患儿为研究对象，按照随机数字表法将所有患儿分为对照组和治疗组，每组各61例。对照组患儿口服盐酸西替利嗪滴剂，1 mL/次，1次/d。治疗组患儿在对照组治疗的基础上口服香菊胶囊，2～4粒/次，3次/d。两组患儿连续服用4周。观察两组的临床疗效，比较两组患儿血清免疫球蛋白、免疫功能、炎症因子水平。结果 治疗后，治疗组的总有效率95.08%，明显高于对照组的总有效率81.97%（P<0.05）。治疗后，治疗组患儿鼻塞、流涕、喷嚏、鼻痒缓解时间明显短于对照组（P<0.05）。治疗后，两组血清免疫球蛋白E（IgE）、免疫球蛋白G（IgG）、白三烯B4（TB4）水平明显低于治疗前（P<0.05）；治疗后，治疗组血清IgE、IgG、LTB4水平低于对照组（P<0.05）。治疗后，两组血清CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺水平明显高于治疗前（P<0.05）；治疗组血清CD3⁺、CD4⁺、CD4⁺/CD8⁺水平明显高于对照组，血清CD8⁺水平低于对照组（P<0.05）。治疗后，两组血清白细胞介素-8（IL-8）、白细胞介素-4（IL-4）、白细胞介素-17（IL-17）水平均明显低于治疗前（P<0.05）；治疗组血清IL-4、IL-8、IL-17水平均低于对照组（P<0.05）。结论 香菊胶囊联合盐酸西替利嗪滴剂治疗儿童过敏性鼻炎具有较好的临床疗效，可有效提高患儿机体免疫能力，降低炎症反应，且安全性较好。

Objective To investigate the clinical effect of Xiangju Capsules combined with Cetirizien Hydrochloride Drops in treatment of allergic rhinitis in children. Methods Children (122 cases) with allergic rhinitis in Wuxi Xinwu District Xinrui Hospital from September 2020 to March 2022 were divided into control and treatment groups according to the random number table method, and each group had 61 cases. Patients in the control group were po administered with Cetirizien Hydrochloride Drops, 1 mL/time, once daily. Patients in the treatment group were po administered with Xiangju Capsules on the basis of the control group, 2-4 capsules/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the serum immunoglobulin, immune function, and inflammatory factors levels in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.08%, significantly higher than the total effective rate of the control group of 81.97% (P < 0.05). After treatment, the remission time of nasal congestion, runny nose, sneezing, and itching in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the serum levels of IgE, IgG, and LTB4 in two groups were significantly lower than before treatment (P < 0.05). After treatment, the serum levels of IgE, IgG, and LTB4 in the treatment group were lower than those in the control group (P< 0.05). After treatment, the serum levels of CD3⁺, CD4⁺, CD8⁺, and CD4⁺/CD8⁺ in two groups were significantly higher than those before treatment (P < 0.05). The levels of serum CD3⁺, CD4⁺, CD4⁺/CD8⁺in the treatment group were significantly higher than those in the control group, while the levels of serum CD8⁺were lower than those in the control group (P < 0.05). After treatment, the levels serum of IL-4, IL-8, and IL-17 in both groups were significantly lower than those before treatment (P < 0.05). The serum levels of IL-4, IL-8, and IL-17 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Xiangju Capsules combined with Cetirizien Hydrochloride Drops is effective in treatment of allergic rhinitis in children, which can significantly reduce the inflammatory reaction of children, improve immune function, and have good safety.

R976