目的 探讨除湿止痒软膏联合曲咪新乳膏治疗儿童湿疹的临床疗效。方法 选取在2021年9月—2022年9月郑州大学附属儿童医院收治的118例湿疹患儿，根据随机数字表法将118例患儿分为对照组和治疗组，每组各59例。对照组患儿每日晚上涂抹曲咪新乳膏1次。治疗组在对照组基础上每日早上外用均匀涂抹除湿止痒软膏1次并轻揉。两组患儿连续治疗21 d。观察两组的临床疗效，比较两组患儿的症状消失时间、皮损症状和血清指标水平。结果 治疗后，治疗组的总有效率为94.92%，明显高于对照组的总有效率83.05%，组间比较有显著差异（P<0.05）。治疗后，两组的湿疹面积严重度指数（EASI）评分明显降低（P<0.05），且治疗组的EASI评分明显低于对照组（P<0.05）。治疗后，治疗组瘙痒、疼痛、红肿消失时间明显短于对照组（P<0.05）。治疗后，两组的血清白细胞介素-4（IL-4）、白细胞介素-18（IL-18）、白细胞介素-23（IL-23）水平明显降低（P<0.05），治疗组的血清IL-4、IL-18、IL-23水平明显低于对照组（P<0.05）。结论 除湿止痒软膏联合曲咪新乳膏有助于提高儿童湿疹的疗效，显著减轻临床症状，降低炎症反应，安全性良好。

Objective To investigate the clinical effect of Chushi Zhiyang Ointments combined with Triamcinolone Acetonide Acetate and Miconazole Nitrate and Neomycin Sulfate Cream in treatment of children eczema. Methods Children (118 cases) with eczema in Children's Hospital Affiliated to Zhengzhou University from September 2021 to September 2022 were divided into control and treatment groups according to the random number table method, and each group had 59 cases. Patients in the control group were daubed with Triamcinolone Acetonide Acetate and Miconazole Nitrate and Neomycin Sulfate Creams, once every night. Patients in the treatment group were daubed with Chushi Zhiyang Ointments on the basis of the control group, once every morning and gently rubbed. Patients in two groups were treated for 21 d. After treatment, the clinical efficacies were evaluated, and the time of symptom disappearance, skin lesion symptoms, and serum indicator levels between two groups were compared. Results After treatment, the total effective rate of the treatment group was 94.92%, which was significantly higher than that of the control group (83.05%), and there was a significant difference between the groups (P < 0.05). After treatment, the EASI score of two groups was significantly decreased (P< 0.05), and the EASI score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the disappearance times of pruritus, pain, and redness in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the serum levels of IL-4, IL-18, and IL-23 in two groups were significantly decreased (P < 0.05), and the serum levels of IL-4, IL-18, and IL-23 in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Chushi Zhiyang Ointments combined with Triamcinolone Acetonide Acetate and Miconazole Nitrate and Neomycin Sulfate Cream can improve the efficacy of children with eczema, significantly reduce clinical symptoms, reduce inflammatory response, with good safety.

R976

河南省医学科技攻关计划项目（LHGJ20210638）