目的 探究清咳平喘颗粒治疗小儿支气管哮喘急性期（热哮证）的临床疗效。方法 选取2019年5月—2021年12月就诊于山东中医药大学附属医院、山东中医药大学第二附属医院及济南市中医院儿科门诊及住院60名支气管哮喘患儿为研究对象，借助SAS 13.0软件产生患者随机表将患者分为对照组和治疗组，每组各30例。对照组患者给予吸入用布地奈德混悬液1 mg/次，2次/d，硫酸特布他林雾化液2.5 mg/次，2次/d。治疗组在对照组治疗基础上口服清咳平喘颗粒，3～6岁，1/2袋/次；7～12岁，1袋/次，3次/d。两组疗程均为5 d。观察两组的临床疗效，比较两组治疗前后中医证候评分和肺功能指标的变化情况。结果 治疗后，治疗组综合疗效总有效率为100%，显著高于对照组的86.7%（P<0.05）。治疗组中医证候疗效总有效率是100.0%，显著高于对照组的86.7%（P<0.05）。治疗后，两组喘息评分、咳嗽咯痰评分、流涕评分、舌脉评分、中医证候总积分均较治疗前显著降低（P<0.05）；且治疗后，治疗组中医证候各评分及总分均显著低于对照组（P<0.05）。治疗后，两组用力肺活量（FVC）、第1秒用力呼气容积FEV1占预计值百分比（FEV1%）、呼气峰流速PEFR占预计值的百分数（PEFR%）均较同组治疗前显著提高（P<0.05）；且治疗后，治疗组FVC、FEV1%、PEFR%水平高于对照组（P<0.05）。结论 清咳平喘颗粒治疗小儿支气管哮喘急性期（热喘证）具有较好的临床疗效，可显著缓解患儿咳嗽、咯痰、喘息等症状，改善肺功能相关指标。

Objective To study the clinical efficacy of Qingke Pingchuan Granules in treatment of acute stage of bronchial asthma in children (heat asthma syndrome). Methods Sixty children with bronchial asthma admitted to the Affiliated Hospital of Shandong University of Chinese Medicine, the Second Affiliated Hospital of Shandong University of Chinese Medicine and Jinan Hospital of Traditional Chinese Medicine from May 2019 to December 2021 were selected as the research objects. The patients were divided into control group and treatment group with 30 cases in each group by using SAS 13.0 software to generate patient randomization table. Patients in the control group were given Budesonide Suspension for inhalation 1 mg/time, twice daily, Terbutaline Sulphate Solution for nebulization 2.5 mg/time, twice daily. Patients in the treatment group were po administered with Qingke Pingchuan Granules on the basis of the control group, 3 to 6 years old, 1/2 bag/time; 7 to 12 years old, 1 bag/time, 3 times/day. The treatment course of bothgroups was 5 d. The clinical effects of the two groups were observed, and the changes of TCM syndrome scores and lung function indexes before and after treatment were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 100%, significantly higher than that of the control group (86.7%) (P < 0.05). The total effective rate of the treatment group was 100.0%, which was significantly higher than that of the control group (86.7%) (P < 0.05). After treatment, panting score, cough phlegm score, runny nose score, tongue and pulse score and total TCM syndrome score were significantly decreased in two groups compared with before treatment (P < 0.05). After treatment, TCM syndrome scores and total scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, forced vital capacity (FVC), the percentage of forced expiratory volume in the first second to the predicted value (FEV1%), and the percentage of PEFR in the predicted value (PEFR%) in the two groups were significantly increased compared with those before treatment (P < 0.05). After treatment, the levels of FVC, FEV1% and PEFR% in the treatment group were higher than those in the control group (P < 0.05). Conclusion Qingke Pingchuan Granules has good clinical effect in treatment of acute stage of bronchial asthma in children (heat asthma syndrome), and can significantly relieve cough, phlegm, wheezing and other symptoms in children, and also can improve lung function indicators.

R974

山东省科技发展计划项目（2014GSF119005）