目的 观察金刚藤胶囊联合布洛芬治疗原发性痛经的临床疗效。方法 选择2019年6月—2021年12月在安徽理工大学第一附属医院就诊的96例原发性痛经患者，按照随机数字表法分为对照组（48例）和治疗组（48例）。对照组经前2～3 d口服布洛芬缓释胶囊，1粒/次，2次/d。治疗组在对照组基础上口服金刚藤胶囊，4粒/次，3次/d。两组患者连续治疗3个月经周期。观察两组患者临床疗效，比较治疗前后两组患者疼痛评分，血清β-内啡肽、前列腺素E₂（PGE₂）、P物质（SP）和血小板活化因子（PAF）水平。结果 治疗后，治疗组的总有效率（93.75%）明显高于对照组（75.00%，P＜0.05）。治疗后，两组患者疼痛总频率评分和严重程度评分明显下降（P＜0.05），且治疗组明显低于对照组（P＜0.05）。治疗后，两组血清β-内啡肽水平明显升高，而PGE₂、SP和PAF水平明显下降（P＜0.05），且治疗组改善程度明显好于对照组（P＜0.05）。结论 金刚藤胶囊联合布洛芬治疗原发性痛经，可有效减轻疼痛症状，改善血清PGE₂、SP、PAF、β-内啡肽水平。

Objective To observe the clinical effect of Jingangteng Capsules combined with ibuprofen in treatment of primary dysmenorrhea. Methods Patients (96 cases) with primary dysmenorrhea in the First Hospital of Anhui University of Science & Technology from June 2019 to December 2021 were divided into control (48 cases) and treatment (48 cases) group by the random number table method. Patients in the control group was po administered with Ibuprofen Sustained-Release Capsules 2 — 3 d before menstruation, 1 grain/time, twice daily. Patients in the treatment group were po administered with Jingangteng Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 3 menstrual cycles. After treatment, the clinical evaluation was evaluated, and the pain scores, the levels of serum β-Endorphin, PGE₂, SP, and PAF in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (93.75%) was significantly higher than that of the control group (75.00%, P < 0.05). After treatment, the total frequency score and severity score of pain in two groups were significantly decreased (P < 0.05), and which in the treatment group were significantly lower than that in the control group (P < 0.05). After treatment, the level of serum β-endorphin in two groups was significantly increased, while the levels of PGE₂, SP, and PAF were significantly decreased (P < 0.05), and these indicators in the treatment group were significantly better than that in the control group (P < 0.05). Conclusion Jingangteng Capsules combined with ibuprofen in treatment of primary dysmenorrhea can effectively relieve pain symptoms and improve the levels of serum PGE2, SP, PAF and β-endorphin.

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