目的 观察清宣止咳颗粒联合磷酸奥司他韦颗粒治疗甲型流感的临床疗效。方法 选取2021年11月份广西中医药大学第一附属医院诊治的104例甲型流感患儿为研究对象，按照随机数字表法分为对照组和治疗组，每组各52例。对照组口服磷酸奥司他韦颗粒，每日10:00及20:00各1次，体质量≤15 kg，30 mg；体质量15～23 kg，45 mg；体质量23～40 kg，60 mg；体质量＞40 kg，75 mg。治疗组在对照组治疗基础上口服清宣止咳颗粒，1～3岁每次1/2包，4～6岁每次3/4包，7～14岁每次1包，均3次/d。两组均连续治疗5 d。观察两组的临床疗效，比较两组咽喉疼痛、发热、卡他症状及头身疼痛的持续时间。观察两组的不良反应发生情况。结果 治疗后，治疗组总有效率是90.4%，对照组总有效率是88.5%，两组总有效率比较差异无统计学意义。治疗后，治疗组发热、咽喉肿痛、卡他症状及头身疼痛持续时间均较对照组明显缩短，两组比较差异具有统计学意义（P＜0.05，0.01）。治疗后，治疗组和对照组不良反应发生率分别是23.1%、21.2%，两组比较差异没有统计学意义。结论 清宣止咳颗粒联合奥司他韦治疗儿童甲型流感的临床疗效较好，可缩短流感相关症状持续时间，且具有良好的安全性。

Objective To observe the clinical efficacy of Qingxuan Zhike Granules combined with oseltamivir phosphate in treatment of influenza A in children. Methods A total of 104 children diagnosed and treated with influenza A in the First Affiliated Hospital of Guangxi University of Chinese Medicine in November 2021 were selected as the study objects, and were divided into control group and treatment group according to random number table method, with 52 cases in each group. Patients in the control group were po administered with Oseltamivir Phosphate Granules, at 10 o’clock and 20 o’clock, body weight ≤ 15 kg, 30 mg, body weight 15 — 23 kg, 45 mg, body weight 23 — 40 kg, 60 mg, body weight > 40 kg, 75 mg. Patients in the treatment group were po administered with Qingxuan Zhike Granules on the basis of the control group, 1/2 pack each time for 1 to 3 years old, 3/4 pack each time for 4 to 6 years old, and 1 pack each time for 7 to 14 years old, 3 times daily. Both groups were treated continuously for 5 d. The clinical efficacy of the two groups was observed, and the duration of throat pain, fever, catarrhal symptoms and head and body pain was compared between the two groups. The occurrence of adverse reactions in the two groups was observed. Results After treatment, the total effective rate was 90.4% in the treatment group and 88.5% in the control group. There was no statistical significance in the total effective rate between the two groups. After treatment, the duration of fever, sore throat, catarrhal symptoms and head and body pain in the treatment group was significantly shorter than that in the control group, with statistical significance (P < 0.01, 0.05). After treatment, the incidence of adverse reactions in the treatment group and the control group was 23.1% and 21.2%, respectively, and there was no statistical significance between the two groups. Conclusion Qingxuan Zhike Granules combined with oseltamivir phosphate has good clinical effect in treatment of influenza A in children, and can shorten the duration of influenza-related symptoms, which has good safety.

R975;R985