目的 探讨补肺活血胶囊联合沙丁胺醇治疗缓解期慢性肺心病的临床疗效。方法 选择2018年6月—2021年6月濮阳市中医医院收治的86例缓解期慢性肺心病患者，按照随机数字表法分为对照组（43例）和治疗组（43例）。对照组口服硫酸沙丁胺醇片，2片/次，3次/d。治疗组在对照组的基础上口服补肺活血胶囊，4粒/次，3次/d。两组用药14 d观察效果。观察两组患者临床疗效，比较治疗前后两组患者症状改善时间，肺功能第1秒用力呼气量（FEV1）、用力肺活量（FVC）和FEV1/FVC指标，心功能心脏每搏量（SV）、心脏心输出量（CO）、心脏指数（CI）指标，血清炎性因子肿瘤坏死因子-α（TNF-α）、转化生长因子-β1（TGF-β1）、白细胞介素-8（IL-8）、血管内皮素（ET-1）水平及不良反应情况。结果 治疗后，治疗组患者总有效率（95.35%）明显高于对照组（81.40%，P＜0.05）。治疗后，治疗组患者症状改善时间比对照组明显缩短（P＜0.05）。治疗后，两组患者FEV1、FVC、FEV1/FVC、SV、CO、CI比治疗前明显升高，而血清炎性因子TGF-β1、ET-1、TNF-α和IL-8水平比治疗前明显降低（P＜0.05），且治疗后治疗组肺功能和心功能指标明显高于对照组（P＜0.05），血清炎性因子水平明显低于对照组（P＜0.05）。治疗后，治疗组不良反应总发生率为9.30%，明显低于对照组（16.28%，P＜0.05）。结论 补肺活血胶囊联合沙丁胺醇治疗缓解期慢性肺心病效果确切，能显著提高心肺功能，减弱机体炎性反应，且不良反应低。

Objective To explore the clinical study of Bufei Huoxue Capsules combined with salbutamol in treatment of chronic cor pulmonale in remission. Methods Patients (86 cases) with chronic cor pulmonale in remission in Chinese Medicine Hospital of Puyang from June 2018 to June 2021 were divided into control (43 cases) and treatment (43 cases) group by the random number table method. Patients in the control group was po administered with Salbutamol Sulfate Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Bufei Huoxue Capsules on the basis of the control group, 4 pills/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated, and the improvement time of symptom, the pulmonary function indexes of FEV1, FVC, and FEV1/FVC, cardiac function index of SV, CO, and CI, level of serological index TGF-β1, ET-1, TNF-α, and IL-8, and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (95.35%) was significantly higher than that of the control group (81.40%, P < 0.05). After treatment, the improvement time of symptom in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the indexes of FEV1, FVC, FEV1/FVC, SV, CO, and CI in two groups were significantly higher than those before treatment, while the levels of TGF- β 1, ET-1, TNF- α, and IL-8 were significantly lower than those before treatment (P < 0.05). After treatment, the indexes of pulmonary function and cardiac function in the treatment group were significantly higher than those in the control group (P < 0.05), and the level of serum inflammatory factors in the treatment group was significantly lower than that in the control group (P < 0.05). After treatment, the total incidence of adverse reactions in the treatment group was 9.30%, which was significantly lower than that in the control group (16.28%, P < 0.05). Conclusion Bufei Huoxue Capsules combined with salbutamol is effective in the treatment of chronic cor pulmonale in remission stage, which can significantly improve cardiopulmonary function and weaken inflammatory reaction, and the adverse reaction is low.

R972

河南省医学科技攻关计划项目（LHGJ20190501）