偏头痛是世界范围内致残的主要原因。5-羟色胺（5-HT）受体在偏头痛中发挥不可替代的作用，其中5-HT1、5-HT2、5-HT3和5-HT7受体是在偏头痛、神经性疼痛中研究最多的受体。偏头痛的早期治疗药物包括特异性药物，如曲坦类药物和麦角类生物碱。拉米地坦作为一种5-HT1F受体激动剂在不同人群中具有较好优势。总结了5-HT受体参与偏头痛的发病机制和药物作用机制，归纳了作用于5-HT受体的抗偏头痛药物曲坦类药物、麦角类生物碱和拉米地坦，以期为偏头痛治疗提供新的思路。

Migraine is the main cause of disability worldwide. 5-Hydroxytryptamine (5-HT) receptors play an irreplaceable role in migraine, and 5-HT1, 5-HT2, 5-HT3, and 5-HT7 receptors are the most studied receptors in migraine and neuropathic pain. Early treatment drugs for migraine include specific drugs, such as triptans and ergot alkaloids. As a 5-HT1F receptor agonist, lamiditan has better advantages in different populations. In this paper, we summarized the pathogenesis and drug action mechanism of 5-HT receptor in migraine, and summarized the anti-migraine drugs, such as triptans, ergot alkaloids and lamiditan, which act on 5-HT receptor, in order to provide new ideas for the treatment of migraine.

R971