目的 探讨康妇灵片联合甲硝唑呋喃唑酮栓治疗慢性宫颈炎的临床疗效。方法 选取2020年7月—2022年5月南阳市中心医院妇科收治的116例慢性宫颈炎患者，按照随机数字表法分为对照组和治疗组，每组各58例。对照组患者给予阴道外用甲硝唑呋喃唑酮栓，用一次性手套将药栓置入阴道后穹窿部位，睡前用药，1枚/次，隔日1次。治疗组在对照组的基础上口服康妇灵片，3片/次，3次/d。两组均连续用药7 d。观察两组的临床疗效，比较两组生活质量评分量表（ST-36）评分、临床症状改善时间、氧化应激反应和血清炎症因子水平。结果 治疗后，治疗组患者总有效率是98.27%，显著高于对照组的82.76%（P＜0.05）。治疗后，治疗组出现阴道分泌物增多、不规则阴道出血、外阴瘙痒、下腹酸痛等症状改善时间均显著短于对照组（P＜0.05）。治疗后，两组患者SF-36评分均较治疗前显著升高（P＜0.05），治疗后，治疗组SF-36评分高于对照组（P＜0.05）。治疗后，两组超氧化物歧化酶（SOD）、一氧化氮（NO）水平均较治疗前显著升高，丙二醛（MDA）、血浆内皮素（ET-1）水平显著降低（P＜0.05）；治疗后，治疗组SOD、NO水平高于对照组，MDA、ET-1水平低于对照组（P＜0.05）。治疗后，两组白细胞介素-2（IL-2）、转化生长因子-β（TGF-β）水平均较治疗前显著降低，血管内皮生长因子（VEGF）、干扰素γ（IFN-γ）水平显著升高（P＜0.05）；治疗后，治疗组血清因子水平改善优于对照组（P＜0.05）。治疗后，治疗组不良反应发生率是6.89%，显著低于对照组的15.52%（P＜0.05）。结论 康妇灵片联合甲硝唑呋喃唑酮栓治疗慢性宫颈炎具有较好的临床疗效，可显著提高患者生活质量，有效调节机体氧化应激反应和炎性反应，值得临床推广应用。

Objective To investigate the clinical study of Kangfuling Tablets combined with Metronidazole and Furazolidone Suppositories in treatment of chronic cervicitis. Methods A total of 116 patients with chronic cervicitis admitted to the Department of Gynecology of Nanyang Central Hospital from July 2020 to May 2022 were selected and divided into control group and treatment group according to random number table method, with 58 cases in each group. Patients in the control group were given Metronidazole and Furazolidone Suppositories, use disposable gloves to put the suppository into the posterior fornix of the vagina before bed, 1 piece/time, once every other day. Patients in the treatment group were po administered with Kangfuling Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, the quality of Life Rating Scale (ST-36) score, clinical symptom improvement time, oxidative stress response and serum inflammatory factor levels were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 98.27%, which was significantly higher than that of the control group (82.76%, P< 0.05). After treatment, the improvement time of symptoms such as increased vaginal secretions, irregular vaginal bleeding, vulva pruritus and abdominal soreness in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, SF-36 scores in both groups were significantly higher than before treatment (P < 0.05), and after treatment, SF-36 scores in the treatment group were higher than those in the control group (P < 0.05). After treatment, the levels of superoxide dismutase (SOD) and nitric oxide (NO) in 2 groups were significantly increased compared with before treatment, while malondialdehyde (MDA) and plasma endothelin (ET-1) were significantly decreased (P < 0.05). After treatment, SOD and NO levels in the treatment group were higher than those in the control group, MDA and ET-1 were lower than those in the control group (P < 0.05). After treatment, the levels of interleukin-2 (IL-2) and transforming growth factor-β (TGF-β) were significantly decreased, while the levels of vascular endothelial growth factor (VEGF) and interferon γ (IFN-γ) were significantly increased in both groups (P < 0.05). After treatment, the improvement of serum factor level in treatment group was better than that in control group (P < 0.05). After treatment, the incidence of adverse reactions in the treatment group was 6.89%, significantly lower than that in the control group (15.52%) (P < 0.05). Conclusion Kangfuling Tablets combined with Metronidazole and Furazolidone Suppositories has good clinical effect in treatment of chronic cervicitis, and can significantly improve the life quality of patients, effectively regulate the oxidative stress and inflammatory response of the body, which is worthy of clinical application.

R984

河南省科技发展计划项目（182102311190）