目的 探讨金水宝胶囊联合来氟米特片治疗慢性肾小球肾炎的临床疗效。方法 选取2018年8月—2021年12月万宁市人民医院收治的79例慢性肾小球肾炎患者，按照随机数字表法将所有患者分为对照组（39例）和治疗组（40例）。对照组口服来氟米特片，2片/次，1次/d。治疗组在对照组基础上饭后30 min口服金水宝胶囊，5粒/次，3次/d。两组患者连续治疗8周。观察两组的临床疗效，比较两组的24 h尿蛋白定量（24 h Upro）、红细胞（RBC）、胱抑素C（Cys-C）、中性粒细胞明胶酶相关脂质运载蛋白（NGAL）、视黄醇结合蛋白（RBP）、尿微量白蛋白（mALB）。结果 治疗后，治疗组的总有效率为95.00%，对照组的总有效率为79.49%，差异有统计学意义（P＜0.05）。治疗后，两组的24 h Upro、RBC、Cys-C明显低于治疗前（P＜0.05），且治疗组的24 h Upro、RBC、Cys-C低于对照组，差异有统计学意义（P＜0.05）。治疗后，两组的血清NGAL、RBP、mALB水平显著降低（P＜0.05），治疗组血清NGAL、RBP、mALB水平显著低于对照组（P＜0.05）。结论 金水宝胶囊联合来氟米特片治疗慢性肾小球肾炎的疗效确切，能改善肾功能，减轻肾组织损伤，安全性良好。

Objective To investigate the clinical efficacy of Jinshuibao Capsules combined with Leflunomide Tablets in treatment of chronic glomerulonephritis. Methods Patients (79 cases) with chronic glomerulonephritis in Wanning People’s Hospital from August 2018 to December 2021 were divided into the control group (39 cases) and the treatment group (40 cases) according to the random number table method. Patients in the control group were po administered with Leflunomide Tablets, 2 tablets/time, once daily. Patients in the treatment group were po administered with Jinshuibao Capsules 30 min after meal on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and the 24 h Upro, RBC, Cys-C, NGAL, RBP, and mALB in two groups were compared. Results After treatment, the total effective rate was 95.00% in the treatment group and 79.49% in the control group, with a statistically significant difference (P < 0.05). After treatment, the 24 h Upro, RBC, and Cys-C in two groups were significantly lower than those before treatment (P < 0.05), and the 24 h Upro, RBC, and Cys-C in the treatment group were lower than those in the control group, with a statistically significant difference (P < 0.05). After treatment, the serum levels of NGAL, RBP, and mALB in two groups were significantly reduced (P< 0.05), and the serum levels of NGAL, RBP, and mALB in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Jinshuibao Capsules combined with Leflunomide Tablets is effective in treatment of chronic glomerulonephritis, can improve renal function, reduce renal tissue damage, and has good safety.

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