目的 探讨盐酸甲氯芬酯胶囊联合醋酸去氨加压素片治疗小儿遗尿症的临床疗效。方法 选择2020年3月—2022年3月在郑州大学附属儿童医院诊治的82例遗尿症患儿，根据服用药物的差别分为对照组和治疗组，每组各41例。对照组口服醋酸去氨加压素片，0.1 mg/次，3次/d；在对照组基础上，治疗组口服盐酸甲氯芬酯胶囊，0.1 g/次，3次/d。两组患儿治疗12周。观察两组患儿临床疗效，比较治疗前后两组患儿尿渗透压和抗利尿激素（ADH）水平，临床症状评分及OSA-18、PSQ和CBCL评分。结果 治疗后，治疗组总有效率为97.56%，显著高于对照组（80.49%，P＜0.05）。治疗后，两组尿渗透压、ADH均明显升高，并以治疗组升高更明显（P＜0.05）。治疗后，两组遗尿次数、遗尿量、睡眠深度、夜间主动排尿等临床症状评分均明显降低（P＜0.05），并以治疗组下降最明显（P＜0.05）。治疗后，两组OSA-18评分和PSQ评分均明显降低，而CBCL评分明显升高（P＜0.05），并以治疗组评分改善最明显（P＜0.05）。结论 盐酸甲氯芬酯胶囊联合醋酸去氨加压素片治疗小儿遗尿症可有效改善患儿症状，提高患儿睡眠，改善患儿生活质量。

Objective To explore the clinical effect of meclofenoxate combined with desmopressin in treatment of enuresis in children. Methods Children (82 cases) with enuresis in Children's Hospital Affiliated to Zhengzhou University from March 2020 to March 2022 were divided into control and treatment group based on differences in drug use, and each group had 41 cases. Children in the control group were po administered with Desmopressin Acetate Tablets, 0.1 mg/time, three times daily. Children in the treatment group were po administered with Meclofenoxate Hydrochloride Capsules on the basis of the control group, 0.1 g/time, three times daily. Children in two groups were treated for 12 weeks. After treatment, the clinical evaluation was evaluated, and the urine osmotic pressure and ADH, the scores of clinical symptom, OSA-18, PSQ and CBCL in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.56%, which was significantly higher than that of the control group (80.49%, P < 0.05). After treatment, the urinary osmotic pressure and ADH increased significantly in two groups (P < 0.05), especially in the treatment group (P < 0.05). After treatment, the number of enuresis score, the amount of enuresis score, the depth of sleep score and nocturnal active urination score were significantly decreased in both groups (P < 0.05), especially in the treatment group (P < 0.05). After treatment, the OSA-18 score and PSQ score were significantly decreased, while the CBCL score was significantly increased in two groups (P < 0.05), and especially in the treatment group (P < 0.05). Conclusion Meclofenoxate combined with Desmopressin Acetate Tablets in treatment of enuresis in children can effectively improve the symptoms, improve their sleep and quality of life.

R985

河南省高等学校重点科研计划项目（19A320017）