目的 探讨沙棘干乳剂联合双歧杆菌三联活菌治疗儿童功能性消化不良的临床疗效。方法 选取2021年5月—2022年7月在漯河市中心医院就诊的70例功能性消化不良患儿，依据随机数字表法将所有患儿分为对照组和治疗组，各35例。对照组口服双歧杆菌三联活菌胶囊，2次/d，2～5岁：1粒/次，5岁以上：2粒/次。治疗组在对照组基础上口服沙棘干乳剂，25 g/次，2次/d，沸水溶解搅拌，乳化后口服。两组连续治疗2周。观察两组患者临床疗效，比较两组患者症状消失时间、胃肠功能指标和血清指标水平。结果 治疗后，治疗组的总有效率为97.14%，高于对照组的总有效率82.86%，差异有统计学意义（P＜0.05）。治疗后，治疗组患儿恶心、腹胀、腹痛、嗳气消失时间短于对照组，差异有统计学意义（P＜0.05）。治疗后，两组的运动指数、收缩频率、收缩幅度明显升高（P＜0.05），治疗组患儿的运动指数、收缩频率、收缩幅度高于对照组（P＜0.05）。治疗后，两组的降钙素基因相关肽（CGRP）、促肾上腺皮质激素释放因子（CRF）水平低于治疗前，瘦素（LEP）水平高于治疗前（P＜0.05）；治疗组儿童的CGRP、CRF水平低于对照组，LEP水平高于对照组，差异有统计学意义（P＜0.05）。结论 沙棘干乳剂联合双歧杆菌三联活菌治疗儿童功能性消化不良的疗效确切，能缩短症状消失时间，改善胃肠功能，调节CGRP、CRF、LEP的分泌。

Objective To investigate the clinical effect of Shaji Dry Emulsion combined with Lactobacillus and Enterococcus Capsules in treatment of functional dyspepsia in children. Methods Children (70 cases) with functional dyspepsia in Luohe Central Hospital from May 2021 to July 2022 were divided into control and treatment groups according to the random number table method, and each group had 35 cases. Children in the control group were po administered with Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules, oral, twice daily, 2-5 years old: 1 grain/time, over 5 years old: 2 grains/time. Children in the treatment group were po administered with Shaji Dry Emulsion on the basis of the control group, dissolve and stir with boiling water, and taken orally after emulsification, 25 g/time, twice daily. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the symptom disappearance time, the gastrointestinal function indexes, and the serum indexes levels in two groups were compared. Results After treatment, the total effective rate of the treatment group was 97.14%, which was higher than that of the control group (82.86%), with a statistically significant difference (P < 0.05). After treatment, the disappearance times of nausea, abdominal distension, abdominal pain, and belching in the treatment group were shorter than those in the control group (P < 0.05). After treatment, the exercise index, contraction frequency, and contraction amplitude of two groups were significantly higher than those before treatment (P < 0.05), and the exercise index, contraction frequency, and contraction amplitude of the treatment group were higher than those of the control group (P < 0.05). After treatment, the levels of CGRP and CRF in two groups were decreased, but the levels of LEP in two groups were increased (P < 0.05). The levels of CGRP and CRF in the treatment group were lower than those in the control group, while the levels of LEP were higher than those in the control group (P < 0.05). Conclusion Shaji Dry Emulsion combined with Bifidobacterium Triple Viable Bacteria has clinical curative effect in treatment of functional dyspepsia in children, can shorten the disappearance time of symptom, improve gastrointestinal function, and regulate the secretion of CGRP, CRF, and LEP.

R975;R985

河南中医药大学第一附属医院科研基金项目（2012KJ34）