炎症性肠病是一种以慢性、复杂性、免疫介导为特点的炎症性疾病,结肠黏膜免疫系统在其发生发展过程中起到了重要作用。黄芩苷是从传统中药黄芩中提取分离出的一种黄酮衍生物,具有显著的药理活性,包括抗炎、调节免疫、抗氧化等。黄芩苷通过影响免疫细胞调节肠道炎症反应、调节免疫活性因子影响肠道免疫、调控信号通路调节肠道免疫、多靶点多角度影响肠道屏障等多种环节、多条通路、多个靶点共同作用来实现治疗炎症性肠病。综述了黄芩苷治疗炎症性肠病的作用机制,以期为进一步开展相关研究提供参考。

Inflammatory bowel disease is a chronic, complex, and immune mediated inflammatory disease, and the immune system of colon mucosa plays an important role in occurrence and development of inflammatory bowel disease. Baicalin is a flavonoid derivative extracted from Scutellariae Radix. It has significant pharmacological activities, including anti-inflammatory, immune regulation, and antioxidant, etc. Baicalin can treat inflammatory bowel disease through multiple links, multiple pathways and multiple targets, including affecting immune cells to regulate intestinal inflammatory response, regulating immune active factors to affect intestinal immunity, regulating signal pathways to regulate intestinal immunity, and affecting intestinal barrier through multiple targets and multiple angles. This article reviews the mechanism of baicalin in treatment of inflammatory bowel disease, hoping to provide reference for further research.

R965

江苏省科技计划专项资金(基础研究计划自然科学基金)项目(BK20221178);江苏省中医药科技发展计划项目(YB2020029);宿迁市基础研究计划-自然科学基金项目(K202144)