[关键词]
[摘要]
目的 探讨益诺胶囊联合卡前列素治疗妊娠产后子宫出血的临床疗效。方法 选择2019年1月-2022年1月在漯河市中心医院诊治的82例产后出血患者,随机分对照组和治疗组,每组各41例。对照组患者肌肉注射卡前列素氨丁三醇注射液,0.25 mg/次,1次/d。在对照组的基础上,治疗组口服益诺胶囊,2粒/次,2次/d。两组治疗5 d。观察两组患者临床疗效,比较治疗前后两组患者症状缓解时间,凝血功能指标凝血酶原时间(PT)、凝血活酶时间(APTT)、纤维蛋白原(FIB)和D-二聚体(D-D),氧化应激指标丙二醛(MDA)、过氧化氢酶(CAT)和超氧化物歧化酶(SOD),及不良反应。结果 治疗后,治疗组总有效率为97.56%,明显高于对照组的78.05%(P<0.05)。治疗后,治疗组症状改善时间均明显短于对照组(P<0.05)。治疗后,两组患者FIB、CAT、SOD指标水平明显升高,而D-D、PT、APTT和MDA指标低于治疗前(P<0.05),且治疗后,治疗组的凝血功能和氧化应激指标均明显好于治疗组(P<0.05)。治疗组不良反应发生率为7.32%,明显低于对照组(17.07%,P<0.05)。结论 益诺胶囊联合卡前列素氨丁三醇治疗妊娠产后子宫出血疗效较好,能有效止血,改善症状,缓解机体氧化应激的能力。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Yinuo Capsules combined with carboprost in treatment of postpartum uterine bleeding during pregnancy. Methods Patients (82 cases) with postpartum hemorrhage in Luohe Central Hospital from January 2019 to January 2022 were randomly divided into control and treatment group, and each had 41 cases. Patients in the control group were intramuscular injection administered with Carboprost Tromethamine Injection, 0.25 mg/time, once daily. Patients in the treatment group po administered with Yinuo Capsules on the basis of the control group, 2 grains/time, twice daily. Patients in two groups were treated for 5 d. After treatment, the clinical evaluation was evaluated, the relief time of symptom, the levels of coagulation index FIB, D-D, PT and APTT, and oxidative stress response index MDA, CAT and SOD, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.56%, which was significantly higher than that of the control group (78.05%) (P<0.05). After treatment, the time of symptom improvement in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the levels of FIB, CAT and SOD in two groups were significantly increased, while the indexes of D-D, PT, APTT and MDA were significantly lower than those before treatment (P<0.05), after treatment, the indexes of blood coagulation and oxidative stress in the treatment group were significantly better than those in the treatment group (P<0.05). The incidence of adverse reactions in the treatment group was 7.32%, which was significantly lower than that in the control group (17.07%, P<0.05). Conclusion The combination of carboprost tromethamine and Yinuo Capsule is effective in stopping bleeding, improving symptoms and relieving oxidative stress.
[中图分类号]
R914
[基金项目]
河南省医学科技攻关计划(联合共建)项目(LHGJ20191417)