目的 探讨八正颗粒联合阿莫西林克拉维酸钾治疗小儿尿路感染的临床疗效。方法 选取2020年3月-2022年3月在郑州大学附属儿童医院泌尿外科治疗尿路感染的106例患儿,按随机数字表法分为对照组和治疗组,每组各53例。对照组口服阿莫西林克拉维酸钾干混悬剂,0.5包/次,每12小时1次。治疗组患者在对照组的基础上开水冲服八正颗粒,1袋/次,3次/d。两组患儿连续用药7 d。观察两组的临床疗效,比较两组临床症状改善时间和血清学因子水平。结果 治疗后,治疗组总有效率是98.11%,显著高于对照组的81.13%(P<0.05)。治疗后,治疗组出现发热、食欲不振、尿频、尿痛改善时间均显著短于对照组(P<0.05)。治疗后,治疗组白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、降钙素原(PCT)、C反应蛋白(CRP)水平均较治疗前显著降低(P<0.05);治疗后治疗组患者血清因子水平均低于对照组(P<0.05)。结论 八正颗粒联合阿莫西林克拉维酸钾治疗小儿尿路感染疗效确切,患儿症状改善较好,能有效降低炎性因子,且安全有效,值的应用。

Objective To investigate the clinical effect of Bazheng Granules combined with amoxicillin and clavulanate potassium in treatment of children with urinary tract infection. Methods A total of 106 children treated for urinary tract infection in Department of Urology of Children’s Hospital Affiliated to Zhengzhou University from March 2020 to March 2022 were selected and divided into control group and treatment group according to random number table method, with 53 cases in each group. Patients in the control group were po administered with Amoxicillin and Clavulanate Potassium for Suspension, 0.5 bag/time, once every 12 h. Patients in the treatment group were po administered with Bazheng Granules on the basis of the control group, 1 bag/time, three times daily. The two groups were continuously treated for 7 d. The clinical efficacy of the two groups was observed, and the improvement time of clinical symptoms and serological factor levels were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 98.11%, which was significantly higher than that of the control group (81.13%, P＜0.05). After treatment, the improvement time of fever, loss of appetite, frequency of urination and pain in the treatment group was significantly shorter than that in the control group (P＜0.05). After treatment, the levels of interleukin-6 (IL-6), interleukin-8 (IL-8), procalcitonin (PCT), and C-reactive protein (CRP) in the treatment group were significantly decreased compared with those before treatment (P＜0.05). After treatment, the serum factor levels in treatment group were lower than those in control group (P＜0.05). Conclusion Bazheng Granules combined with amoxicillin and clavulanate potassium has curative effect in treatment of children with urinary tract infection, and can improved children’s symptoms better, and also can effectively reduce inflammatory factors safely and effectively, which has clinical application of value.

R914

河南省高等学校重点科研项目计划(19A320017)