目的 探讨小儿感冒舒颗粒联合头孢克肟治疗小儿急性细菌性上呼吸道感染的临床疗效。方法 选取2021年1月-2022年5月中国人民解放军联勤保障部队第九四一医院收治的126例急性细菌性上呼吸道感染患儿,按随机数字表法将所有患者分为对照组和治疗组,每组各63例。对照组温开水冲服头孢克肟颗粒,体质量<30 kg患儿每次3 mg/kg,体质量 ≥ 30 kg患儿100 mg/次,2次/d。治疗组在对照组基础上温开水冲服小儿感冒舒颗粒,1~3岁患儿3 g/次,4次/d;4~7岁患儿6 g/次,3次/d;8~12岁患儿6 g/次,4次/d。两组均连续治疗5 d。观察两组临床疗效,比较两组退热效果和局部典型表现消失时间。比较治疗前后两组白细胞计数(WBC)、中性粒细胞百分比(NEUT%)异常率,红细胞沉降率(ESR)及血清降钙素原(PCT)、C反应蛋白(CRP)水平。结果 治疗后,治疗组患儿总有效率是92.31%,显著高于对照组的84.13%(P<0.05)。治疗组即刻退热率47.6%较对照组30.2%显著提高,退热起效时间、完全退热时间均显著短于对照组(P<0.05)。治疗后,治疗组咽痛、鼻塞、流涕、咳嗽消失时间较对照组均显著缩短(P<0.05)。与治疗前相比,两组治疗后WBC、NEUT%异常率均显著降低(P<0.05);且治疗后,治疗组WBC、NEUT%异常率均显著低于对照组(P<0.05)。治疗后,两组ESR和血清PCT、CRP水平均较治疗前显著下降(P<0.05);且均以治疗组降低更显著(P<0.05)。结论 小儿感冒舒颗粒联合头孢克肟治疗小儿急性细菌性上感的总体疗效确切,能迅速缓解患儿症状,促进外周血象恢复,有效减轻机体感染及炎性损伤,且患儿耐受性较好。

Objective To investigate the clinical efficacy of Xiaoer Ganmaoshu Granules combined with cefixime in treatment of children with acute bacterial upper respiratory tract infection. Methods A total of 126 children with acute bacterial upper respiratory tract infection admitted to 941 Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army from January 2021 to May 2022 were selected. All children were divided into control group and treatment group according to random number table method, with 63 cases in each group. Children in the control group were po administered with Cefixime Granules with warm boiled water, body weight＜30 kg were given 3 mg/kg each time, and children with body weight ≥30 kg were given 100 mg/time, twice daily. Children in the treatment group were and C-reactive protein (CRP) levels were compared between the two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 92.31%, which was significantly higher than that of the control group (84.13%, P＜0.05). The immediate antipyretic rate of the treatment group was 47.6%, which was significantly higher than that of the control group (30.2%). The antipyretic onset time and complete antipyretic time of the treatment group were significantly shorter than those of the control group (P＜0.05). After treatment, the disappearance time of sore throat, nasal obstruction, runny nose and cough in the two groups was significantly shorter than that in the control group (P＜0.05). Compared with before treatment, the abnormal rates of WBC and NEUT% in the two groups were significantly decreased after treatment (P＜0.05). After treatment, the abnormal rates of WBC and NEUT% in the treatment group were significantly lower than those in the control group (P＜0.05). After treatment, the levels of ESR, serum PCT and CRP in the two groups were significantly decreased compared with those before treatment (P＜0.05). And the reduction was more significant in the treatment group (P＜0.05). Conclusion Xiaoer Ganmaoshu Granules combined with cefixime has a definite overall effect in treatment of acute bacterial infection in children, and can quickly relieve the symptoms of children, promote the recovery of peripheral blood, effectively reduce the infection and inflammatory damage of the body with good tolerance. po administered with Xiaoer Ganmaoshu Granules with warm boiled water on the basis of the control group, 3 g/time, 4 times daily for children aged 1-3 years. Children aged 4-7 years were given 6 g/time, 3 times daily. Children aged 8-12 years were given 6 g/time, 4 times daily. Both groups were treated for 5 d. The clinical efficacy of the two groups was observed. The antipyretic effect and the disappearance time of local typical manifestations were compared between the two groups. The abnormal rate of white blood cell count (WBC), neutrophil percentage (NEUT%), erythrocyte sedimentation rate (ESR), serum procalcitonin (PCT)

R914

西宁市卫生健康委指导性计划课题(2021-wjzdx-79)