目的 探讨复方杜仲胶囊联合贝那普利治疗老年高血压的临床疗效。方法 选择2020年1月-2022年1月在石家庄市第三医院诊疗的128例老年高血压患者,随机数字表法将患者分为对照组和治疗组,每组各64例。对照组口服盐酸贝那普利片,10 mg/次,1次/d。在对照组的基础上,治疗组口服复方杜仲胶囊,5粒/次,3次/d。两组用药7 d。观察两组患者临床疗效,比较治疗前后两组患者症状缓解时间,收缩压(SBP)和舒张压(DBP),血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、同型半胱氨酸(Hcy)和内皮素-1(ET-1)水平及不良反应情况。结果 治疗后,治疗组的总有效率(98.44%)明显高于对照组(84.37%,P<0.05)。治疗后,治疗组嗜睡、头晕、心悸、目眩缓解时间均明显早于对照组(P<0.05)。治疗后,两组患者SBP、DBP水平明显低于治疗前(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,两组血清IL-6、Hcy、TNF-α、ET-1水平明显低于治疗前(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗期间,治疗组不良反应发生率为7.81%,明显低于对照组(14.06%,P<0.05)。结论 贝那普利与复方杜仲胶囊联合治疗老年高血压能平稳降低血压,纠正血脂异常,降低炎性反应。

Objective To investigate the efficacy of Compound Duzhong Capsules combined with benazepril in treatment of senile hypertension. Methods Patients (128 cases) with senile hypertension in the Third Hospital of Shijiazhuang from January 2020 to January 2022 were divided into control and treatment group according to random number method, and each group had 64 cases. Patients in the control group were po administered with Benazepril Hydrochloride Tablets, 10 mg/time, once daily. Patients in the treatment group po administered with Compound Duzhong Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, the relief time of symptom, SBP, DBP, the levels of IL-6, Hcy, TNF-α, and ET-1, and the adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical therapeutic efficiency of the treatment group (98.44%) was significantly higher than that of the control group (84.37%, P＜0.05). After treatment, the remission time of drowsiness, dizziness, palpitation and dizziness in the treatment group was significantly earlier than that in the control group (P＜0.05). After treatment, the levels of SBP and DBP in two groups were significantly lower than those before treatment (P＜0.05), and those in the treatment group were significantly lower than those in the control group (P＜0.05). After treatment, the serum levels of IL-6, Hcy, TNF-α, and ET-1 in the two groups were significantly lower than those before treatment (P＜0.05), and which in the treatment group were significantly lower than those in the control group (P＜0.05). During the treatment, the adverse reaction rate in the treatment group was 7.81%, which was significantly lower than that in the control group (14.06%, P＜0.05). Conclusion Compound Duzhong Capsules combined with benazepril in treatment of senile hypertension can steadily reduce blood pressure, correct dyslipidemia and reduce inflammatory reaction.

R914

河北省医学研究重点课题计划项目(20201366)