脓毒症相关性急性肾损伤目前被认为是与脓毒症相关的最严重并发症之一，病理生理机制仍不明确。右美托咪定是一种新型高效的α₂肾上腺素受体激动剂。在脓毒症中，右美托咪定可通过抗炎、抗氧化应激、增强自噬调节、影响血流动力学来保护肾脏功能，因此就右美托咪定对脓毒症肾脏功能的保护作用的研究进展进行了综述。

Sepsis-associated acute kidney injury is currently considered as one of the most serious complications associated with sepsis, and its pathophysiological mechanism is still unclear. Dexmedetomidine is a novel and efficient α₂-adrenergic receptor agonist. In sepsis, dexmedetomidine may protect kidney function by anti-inflammatory, anti-oxidative stress, enhancing autophagy regulation, and affecting hemodynamics. This article reviews the research progress on protection of dexmedetomidine on renal function in sepsis.

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