精神分裂症是一种严重精神疾病，患者需要长期甚至终身服用抗精神病药物。长期使用非典型抗精神病药物会引起患者葡萄糖耐量降低、血糖升高和血脂异常，使心血管疾病和2型糖尿病的发病风险增加。关注非典型抗精神病药物诱导的糖脂代谢异常，阐明其发病机制，有助于早期疾病检测和药物个体化选择，对预防药物不良反应的发生和提高临床疗效至关重要。综述了精神分裂症患者使用非典型抗精神病药物引起的糖脂代谢异常及其机制的研究进展，并提出药物干预对策，为非典型抗精神病药物的安全应用提供参考。

Schizophrenia is a serious mental disease, and patients need to take antipsychotics for a long time or even for life. Long term use of atypical antipsychotics will lead to decreased glucose tolerance, increased blood sugar and abnormal blood lipids in patients with schizophrenia, and increase the risk of cardiovascular disease and type 2 diabetes. Paying attention to the abnormal glucose and lipid metabolism induced by atypical antipsychotics and clarifying its pathogenesis are helpful for early disease detection and individualized drug selection, and is very important to prevent the occurrence of adverse drug reactions and improve clinical efficacy. This article reviewed the research progress on abnormal glucose and lipid metabolism caused by atypical antipsychotics used in schizophrenia patients and its mechanism, and proposed drug intervention strategies to provide reference for the safe application of atypical antipsychotics.

R964;R977

山东省第一批药品临床综合评价项目（2021YZ026）；潍坊市药品临床综合评价项目（2022WFYP02）