口腔恶性肿瘤是头颈部常见病变，是发生于口腔部位的恶性肿瘤总称，包括牙龈癌、口咽癌、唇癌、舌癌、口腔鳞状细胞癌等。口腔恶性肿瘤在临床上多采用综合治疗手段。姜黄素是从姜黄、郁金中提取的活性成分，可以通过诱导细胞凋亡、抑制细胞增殖、降低肿瘤细胞侵袭力、诱导细胞自噬、抗氧化作用、抗炎作用、抗口腔纤维化、提高放化疗疗效等多种途径发挥显著的抗口腔癌作用。对姜黄素防治口腔恶性肿瘤的作用机制进行综述，以期为姜黄素的临床运用提供参考。

Oral malignant tumor is a common pathological change of head and neck, and it is a general term for malignant tumors that occur in the oral cavity, including gum cancer, oropharyngeal cancer, lip cancer, tongue cancer, oral squamous cell carcinoma, etc. Oral malignant tumors are mostly treated with comprehensive treatment in clinical. Curcumin is the active ingredient from Curcumae Longae Rhizoma and Curcumae Radix, which can play a significant anti-cancer effect by inducing apoptosis, inhibiting cell proliferation, reducing tumor cell invasiveness, inducing autophagy, anti-oxidation, anti-inflammatory, anti-oral fibrosis, improving the curative effect of chemoradiotherapy and other ways. This paper reviews the mechanism of curcumin in prevention and treatment of oral malignant tumors, hoping to provide a reference for the clinical application of curcumin.

R988.2;R979.1

河北省卫生健康委医学科学研究课题计划（20171377）