子痫前期是妊娠期特发疾病，是新生儿和产妇发病和死亡的主要原因，因此探索安全有效的预防和治疗药物是重要途径。二甲双胍在妊娠早期是安全的，没有先天畸形的风险，可以作为一种治疗子痫前期有前景的候选药物。二甲双胍通过促进血管生成和保护内皮细胞、抗炎和抑制氧化应激、对抵抗危险因素的滋养细胞保护作用而对子痫前期具有防治作用，同时二甲双胍可以降低孕妇发生子痫前期的风险，延长早产子痫前期孕妇的妊娠期。因此总结了二甲双胍防治子痫前期的作用机制和临床研究，以期为二甲双胍临床上治疗子痫前期提供参考。

Preeclampsia is an idiopathic disease in pregnancy, which is the leading cause of neonatal and maternal morbidity and mortality, and exploring safe and effective preventive and therapeutic drugs is an important way. Metformin is safe in early pregnancy, without the risk of congenital malformation, and can be used as a promising candidate drug for treatment of preeclampsia. Metformin can prevent and treat preeclampsia by promoting angiogenesis, protecting endothelial cells, anti-inflammatory, inhibiting oxidative stress, and protecting trophoblasts against risk factors. In the same time, metformin can reduce the risk of preeclampsia in pregnant women and prolong the pregnancy period of preterm preeclampsia pregnant women. This article reviewed the mechanism and clinical research of metformin in prevention and treatment of preeclampsia, hoping to provide a reference for metformin in clinical treatment of preeclampsia.

R984

国家临床重点专科建设目标（晋卫办医函[2021]113号）；山西医科大学第一医院院基金项目（YY2215）