目的 评价脉络宁注射液在临床使用的安全性，挖掘可能造成脉络宁注射液不良反应的相关因素，为今后临床安全使用提供警示和参考。方法 在中国知网、万方数据库、维普数据库中以“脉络宁注射液”“注射用脉络宁”“797注射液”“脉络宁”“不良反应”“不良事件”“用药错误”“高警示药品”“过敏性休克”为关键词检索脉络宁注射液所致不良反应的文献，并进行整理和分析。结果 共筛选出文献131篇，189个案例。结果表明，脉络宁注射液致不良反应多发生于45～74岁患者，以免疫系统和呼吸系统占多数（75.6%），脉络宁注射液不良反应以速发型为主，主要出现在用药15min以内，发生不良反应的严重程度与脉络宁的使用剂量无显著相关性。结论： 脉络宁注射液在临床使用时应严格把握适应证及使用方法，用药前仔细询问患者过敏史，加强用药监测。

Objective To evaluate the safety of Mailuoning Injection in clinical use, and explore the related factors that may cause adverse reactions of Mailuoning Injection, so as to provide warning and reference for future clinical safe use. Method Literature on adverse reactions caused by Mailuoning Injection was retrieved from CNKI, Wanfang, and VIP database with the key words "Mailuoning Injection"" Mailuoning for injection""797 Injection""Mailuoning""adverse reactions""adverse events""medication errors""high-warning drugs""anaphylactic shock" as keywords, and then sorted and analyzed. Result A total of 131 literatures and 189 cases were selected. The results showed that the adverse reactions caused by Mailuoning Injection mostly occurred in patients aged 45-74 years, and the immune system and respiratory system accounted for the majority (75.6%). Adverse reactions of Mailuoning Injection were mainly rapid onset, which mainly occurred within 15 min of administration. The severity of adverse reactions had no significant correlation with the dosage of Mailuoning Injection. Conclusion In the clinical use of Mailuoning Injection, the indications and the method of use should be strictly grasped, the patient's allergy history should be carefully asked before medication, and the medication monitoring should be strengthened.

R914

中国医药教育协会孙思邈中医药科研专项课题（药教协授字【2016】第164-8号）