[关键词]
[摘要]
目的 分析血栓通注射剂的不良反应,为临床的安全合理用药提供参考。方法 以“血栓通”“不良反应”“不良事件”“Xueshuantong”“adverse reaction”“adverse event”为关键词检索2005年1月—2022年10月中国知网、万方、维普数据库,对血栓通注射剂引起的不良反应进行汇总、分析。结果 共纳入35篇文献,1551例患者,男女比例约1∶1,60岁以上人群居多(69.95%),心脑血管系统疾病患者的不良反应最多(55.51%),不良反应最常出现在用药30min内(37.96%),常累及多个器官系统,以皮肤、肌肉、骨骼系统损害最为常见(56.54%)。结论 临床应用血栓通注射剂时要严格按照药品说明书来使用,用药过程中除了重视血栓通注射剂引起的速发型过敏反应外,还要关注迟发型过敏反应的可能。
[Key word]
[Abstract]
Objective To analyze the adverse reactions of Xueshuantong injection, to provide reference for safe and rational drug use in clinic. Methods Using "Xueshuantong""adverse reaction""Xueshuantong""adverse reaction" and "adverse event" as key words, CNKI, Wanfang, and VIP database from January 2005 to October 2022 was searched. The adverse reactions caused by Xueshuantong Injection were summarized and analyzed. Result A total of 35 literatures were included, including 1 551 patients, with a male to female ratio of 1:1 (69.95%). Patients with cardiovascular and cerebrovascular diseases had the most adverse reactions (55.51%), and adverse reactions most often appeared within 30 min of medication (37.96%), often involving multiple organ systems. The damage of skin, muscle and bone system was the most common (56.54%). Conslusion The clinical application of Xueshuantong injection form should be strictly in accordance with the drug instructions. In the process of medication, attention should be paid to the rapid allergic reaction caused by Xueshuantong Injection, as well as the possibility of delayed allergic reaction.
[中图分类号]
R286.1
[基金项目]