目的 探讨活血止痛胶囊联合双氯芬酸钠治疗急性软组织损伤的临床疗效。方法 选取2020年6月—2022年6月如皋市人民医院收治的90例急性软组织损伤病患，按照随机数字表法分为对照组（45例）和治疗组（45例）。对照组口服双氯芬酸钠缓释胶囊，50mg/次，2次/d。在对照组基础上，治疗组口服活血止痛胶囊，4粒/次，3次/d。两组治疗7d。观察两组患者临床疗效，比较治疗前后两组患者症状改善时间，视觉模拟评分法（VAS），血清炎性因子白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、前列腺素E₂（PGE₂）和白细胞介素-1β（IL-1β）水平及不良反应。结果 治疗后，治疗组患者总有效率（97.78%）明显高于对照组（80.00%，P＜0.05）。与对照组比较，治疗组症状改善更快（P＜0.05）。治疗后，两组VAS评分均明显下降（P＜0.05），且治疗组明显低于对照组（P＜0.05）。治疗后，两组血清炎性因子IL-1β、IL-6、PGE₂、TNF-α水平均明显降低（P＜0.05），且治疗组明显低于对照组（P＜0.05）。治疗后，治疗组不良反应发生率明显低于对照组（P＜0.05）。结论 活血止痛胶囊联合双氯芬酸钠治疗急性软组织损伤效果确切，能有效降低机体炎性因子含量，促进软组织的修复、再生、功能恢复。

Objective To investigate the efficacy of Huoxue Zhitong Capsule combined with diclofenac sodium in treatment of acute soft tissue injury. Methods Patients (90 cases) with acute soft tissue injury in Rugao People's Hospital from June 2020 to June 2022 were divided into control (45 cases) and treatment (45 cases) group according to the random number table method. Patients in the control group were po administered with po Diclofenac Sodium Sustained Release Capsules, 50 mg/time, twice daily. Patients in the treatment group po administered with Huoxue Zhitong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, the improvement time of symptom, VAS scores, the levels of serum factor IL-1β, IL-6, PGE₂, and TNF-α, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of patients in the treatment group (97.78%) was significantly higher than that in the control group (80.00%, P<0.05). Compared with the control group, the symptoms of the treatment group improved faster (P<0.05). After treatment, VAS score in two groups was significantly decreased (P<0.05), and which in the treatment group were significantly lower than that in the control group (P<0.05). After treatment, the levels of serum inflammatory factor IL-1β, IL-6, PGE₂, TNF-α in two groups were significantly lower (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the total incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion The curative effect of Huoxue Zhitong Capsule combined with diclofenac sodium in treatment of acute soft tissue injury is definite, which can effectively reduce the content of inflammatory factors in the body, and promote the repair, regeneration and functional recovery of soft tissues.

R977