目的 探讨虎力散片联合塞来昔布胶囊治疗膝骨关节炎的临床疗效。方法 选取2019年4月—2021年12月来厦门大学附属第一医院康复医学科诊疗的170例膝骨关节炎患者，按照随机数字表法分为对照组和治疗组，每组各85例。对照组口服塞来昔布胶囊，0.2g/次，1次/d。治疗组在对照组的基础上口服虎力散片，0.3g/次，2次/d。两组用药42d。观察两组的临床疗效，比较两组临床症状改善时间、两组疼痛视觉模拟评分（VAS）、骨关节炎指数评分（WOMAC）、白细胞介素-1β（IL-1β）、血管内皮生长因子（VEGF）、转化生长因子-β1（TGF-β1）、肿瘤坏死因子-α（TNF-α）水平。结果 治疗后，治疗组总有效率是98.82%，显著高于对照组的85.88%（P＜0.05）。治疗后，治疗组出现膝关节疼痛、膝关节僵硬、膝关节肿胀、膝关节发冷等症状改善时间均显著短于对照组（P＜0.05）。治疗后，两组VAS评分、WOMAC评分均较治疗前显著降低（P＜0.05）；且治疗后治疗组VAS评分和WOMAC评分低于对照组（P＜0.05）。治疗后，两组患者IL-1β、VEGF、TNF-α水平均较治疗前显著降低，TGF-β1水平显著升高（P＜0.05）；治疗后，治疗组血清因子水平改善优于对照组（P＜0.05）。结论 虎力散片联合塞来昔布胶囊治疗膝骨关节炎的效果确切，可有效缓解膝关节疼痛及改善关节功能，并能减轻机体炎性反应，值得推广应用。

Objective To investigate the therapeutic effect of Hulisan Tablets combined with celecoxib in treatment of knee osteoarthritis. Methods A total of 170 patients with knee osteoarthritis admitted to the Department of Rehabilitation Medicine of the First Affiliated Hospital of Xiamen University from April 2019 to December 2021 were selected and divided into control group and treatment group according to random number table method, with 85 cases in each group. Patients in the control group were po administered with Celecoxib Capsules, 0.2 g/time, once daily. Patients in the treatment group were po administered with Hulisan Tablets, 0.3 g/time, twice daily. Both groups were treated for 42 d. The clinical efficacy of the two groups was observed, and the improvement time of clinical symptoms, pain visual analogue score (VAS), osteoarthritis index score (WOMAC), interleukin-1β (IL-1β), vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β1), tumor necrosis factor (TNF-α) levels were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 98.82%, which was significantly higher than that of the control group 85.88% (P<0.05). After treatment, the improvement time of knee pain, knee stiffness, knee swelling and knee chills in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, VAS score and WOMAC score were significantly decreased in both groups compared with before treatment (P<0.05). After treatment, VAS score and WOMAC score in the treatment group were lower than those in the control group (P<0.05). After treatment, the levels of IL-1β, VEGF and TNF-α were significantly decreased in both groups compared with before treatment, while the level of TGF-β1 was significantly increased (P<0.05). After treatment, the improvement of serum factor level in treatment group was better than that in control group (P<0.05). Conclusion Hulisan Tablets combined with celecoxib have definite therapeutic effects in treatment of knee osteoarthritis, and can effectively relieve knee pain and improve joint function, and reduce the inflammatory reaction of the body, which is worthy of popularization and application.

R977