目的 探讨补肾益脑丸联合甲钴胺治疗耳鸣的临床疗效。方法 选取2018年12月—2021年7月南阳市中心医院收治的94例耳鸣患者，使用随机数字表法将所有患者分为对照组和治疗组，每组各47例。对照组口服甲钴胺片，0.5mg/次，3次/d。治疗组在对照组基础上口服补肾益脑丸，10丸/次，2次/d。两组疗程均为2周。观察两组的临床疗效，比较治疗前后两组耳鸣持续时间评分、耳鸣响度视觉模拟量表（VAS）评分及耳鸣障碍问卷（THQ）、普通话版的耳鸣问卷表（MTQ）、医院焦虑和抑郁量表（HADS）总分。结果 治疗后，治疗组总有效率是89.4%，显著高于对照组的72.3%（P＜0.05）。治疗后，两组耳鸣持续时间评分和耳鸣响度VAS评分均显著低于治疗前（P＜0.05）；且均以治疗组降低更显著（P＜0.05）。治疗后，两组THQ、MTQ和HADS总分均显著降低（P＜0.05）；且治疗组降低更显著（P＜0.05）。结论 补肾益脑丸联合甲钴胺对耳鸣患者具有确切的临床疗效，能安全有效地缓解患者耳鸣症状，减轻耳鸣的不良影响，提高生活质量，改善消极情绪。

Objective To analyze the clinical efficacy of Bushen Yinao Pills combined with mecobalamin in treatment of tinnitus. Methods A total of 94 tinnitus patients admitted to Nanyang Central Hospital from December 2018 to July 2021 were selected. All patients were divided into control group and treatment group by random number table method, with 47 cases in each group. Patients in the control group were po administered with Mecobalamin Tablets, 0.5 mg/time, three times daily. Patients in the treatment group were po administered with Bushen Yinao Pills on the basis of the control group, 10 pills/time, twice daily. Both groups were treated for 2 weeks. The clinical efficacy of the two groups was observed. The tinnitus duration score, tinnitus loudness visual analogue scale (VAS) score, Tinnitus disorder Questionnaire (THQ), Mandarin Tinnitus Questionnaire (MTQ), the total scores of Hospital Anxiety and Depression Scale (HADS) were compared between the two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 89.4%, which was significantly higher than that of the control group (72.3%) (P<0.05). After treatment, the tinnitus duration score and tinnitus loudness VAS score in the two groups were significantly lower than those before treatment (P<0.05). And the reduction was more significant in the treatment group (P<0.05). After treatment, the total scores of THQ, MTQ, and HADS in the two groups were significantly decreased (P<0.05). And the treatment group decreased more significantly (P<0.05). Conclusion Bushen Yinao Pills combined with mecobalamin has a definite clinical effect in treatment of tinnitus, and can safely and effectively relieve the symptoms of tinnitus, reduce the adverse effects of tinnitus, improve the life quality, which can improve negative emotions.

R987

南阳市卫生和计划生育委员会科研项目（ZD201798）