目的 探讨消石利胆胶囊联合茴三硫片治疗慢性胆囊炎的临床疗效。方法 选择2021年3月—2022年3月在濮阳市中医医院治疗的130例慢性胆囊炎患者，按照随机数字表法分为对照组（65例）和治疗组（65例）。对照组患者口服茴三硫片，1片/次，3次/d。在对照组的基础上，治疗组口服消石利胆胶囊，3粒/次，3次/d。两组患者服药8周。观察两组患者临床疗效，比较治疗前后两组患者症状好转时间，胆囊壁厚度积分，血清因子β-内啡肽（β-EP）、白细胞介素-6（IL-6）、超氧化物歧化酶（SOD）和肿瘤坏死因子-α（TNF-α）水平及不良反应。结果 治疗后，治疗组总有效率（98.46%）明显高于对照组（84.62%，P＜0.05）。治疗后，治疗组出现的右上腹隐痛、恶心、腹胀、嗳气等症状好转时间均明显早于对照组（P＜0.05）。治疗后，两组B超胆囊壁厚度积分明显低于治疗前（P＜0.05），且治疗组B超胆囊壁厚度积分明显低于对照组（P＜0.05）。治疗后，两组血清因子IL-6、β-EP、TNF-α水平明显降低，而SOD水平明显升高（P＜0.05），且治疗组血清因子水平明显优于对照组（P＜0.05）。治疗后，治疗组不良反应发生率明显低于对照组（P＜0.05）。结论 茴三硫片与消石利胆胶囊联合治疗慢性胆囊炎效果确切，可有效增加胆囊功能，并能使炎症反应减弱，患者症状好转。

Objective To investigate the curative effect of Xiaoshi Lidan Capsules combined with anethole trithione in treatment of chronic cholecystitis. Methods Patients (130 cases) with chronic cholecystitis in Chinese Medicine Hospital of Puyang from March 2021 to March 2022 were randomly divided into control (65 cases) and treatment (65 cases) group. Patients in the control group were po administered with Anethole Trithione Tablets, 1 tablet/time, three times daily. Patients in the treatment group po administered with Xiaoshi Lidan Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, the improvement time of symptom, B-ultrasound gallbladder wall thickness integral, levels of serum factor IL-6, β-EP, TNF-α, and SOD, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group (98.46%) was significantly higher than that of the control group (84.62%, P<0.05). After treatment, the improvement time of right upper abdominal pain, nausea, abdominal distension, belching and other symptoms in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, the integral of gallbladder wall thickness in two groups was significantly lower than that before treatment (P<0.05), and the integral of gallbladder wall thickness of patients in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the serum levels of IL-6, β-EP, and TNF-α in two groups were significantly decreased, while the level of SOD were significantly increased (P<0.05), and the level of serum factors in the treatment group was significantly better than that in the control group (P<0.05). After treatment, the incidence of adverse events in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion The combination of Xiaoshi Lidan Capsules and anethole trithione in treatment of chronic cholecystitis has a definite effect on chronic cholecystitis, which can effectively increase the gallbladder function, weaken the inflammatory reaction, and improve the symptoms of patients.

R975

河南省中医药科学研究课题（2018ZY3040）