[关键词]
[摘要]
目的 探讨清开灵注射液联合注射用头孢西丁钠治疗急性上呼吸道感染的临床疗效。方法 选取2020年2月—2022年1月秦皇岛市中医医院收治的76例急性上呼吸道感染患者,全部患者按照随机数字表法分为对照组和治疗组,每组各38例。对照组患者静脉滴注注射用头孢西丁钠,2g加入100mL生理盐水中,2次/d。治疗组患者在对照组治疗的基础上静脉滴注清开灵注射液,20mL加入100mL葡萄糖液中,1次/d。两组患者连续治疗7d。观察两组的临床疗效,比较两组的主要症状的消失时间、血清白细胞介素-18(IL-18)、C反应蛋白(CRP)、白细胞(WBC)水平。结果 治疗后,治疗组的总有效率为97.37%,高于对照组的总有效率81.58%,差异有统计学意义(P<0.05)。治疗后,治疗组患者的体温复常时间、咳嗽消失时间、咽部红肿消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的血清IL-18、CRP、WBC水平显著降低(P<0.05);治疗组的血清IL-18、CRP、WBC水平低于对照组,差异有统计学意义(P<0.05)。结论 清开灵注射液联合注射用头孢西丁钠治疗急性上呼吸道感染具有较好的临床疗效,能缓解临床症状,减轻炎症反应,药物安全性良好。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Qingkailing Injection combined with Cefoxitin Sodium for injection in treatment of acute upper respiratory tract infection. Methods Patients (76 cases) with acute upper respiratory tract infection in Qinhuangdao Hospital of Traditional Chinese Medicine from February 2020 to January 2022 were divided into control and treatment groups according to random number table method, and each group had 38 cases. Patients in the control group were iv administered with Cefoxitin Sodium for injection, 2g added into glucose solution 100 mL, twice daily. Patients in the treatment group were iv administered with Qingkailing Injection on the basis of the control group, 20 mL added into glucose solution 100 mL, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the disappearance times of main symptoms, and the serum levels of IL-18, CRP, and WBC in two groups were compared. Results After treatment, the total effective rate of the treatment group was 97.37%, which was higher than that of the control group (81.58%), and the difference was statistically significant (P<0.05). After treatment, the temperature normalization time, cough disappearance time, and pharyngeal swelling disappearance time of the treatment group were shorter than those of the control group, and the difference was statistically significant (P<0.05). After treatment, the serum levels of IL-18, CRP, and WBC in two groups were significantly decreased (P<0.05). The serum levels of IL-18, CRP, and WBC in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Qingkailing Injection combined with Cefoxitin Sodium for injection has clinical curative effect in treatment of acute upper respiratory tract infection, can alleviate clinical symptoms and inflammatory reaction, with good safety.
[中图分类号]
R974
[基金项目]
秦皇岛市市级科学技术研究与发展计划项目(202004A125)