目的 综合评价不同产地苍耳子的质量。方法 采用HPLC法测定不同产地苍耳子中羧基苍术苷、苍术苷、新绿原酸、绿原酸、隐绿原酸、噻嗪双酮苷、1,5-二咖啡酰奎宁酸、3,4-二咖啡酰奎宁酸、3,5-二咖啡酰奎宁酸和4,5-二咖啡酰奎宁酸，采用偏最小二乘判别分析（PLS-DA）和熵权优劣解距离法（EW-TOPSIS）法综合分析测定结果，寻找引起苍耳子产品质量的主要差异性物质，评价不同产地苍耳子质量的优劣。结果 10种成分在各自范围内线性关系良好；绿原酸、1,5-二咖啡酰奎宁酸、3,5-二咖啡酰奎宁酸、羧基苍术苷和新绿原酸是影响苍耳子产品质量的主要潜在标志物；EW-TOPSIS法分析结果显示江苏和山东产的苍耳子质量优。结论 建立的HPLC法操作便捷、结果准确，结合PLS-DA、EW-TOPSIS法可综合评价不同产地苍耳子的质量。

Objective To establish comprehensive quality evaluation for Xanthii Fructus from different producing areas. Methods The contents of carboxyatractyloside, atractyloside, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, xanthiside, 1,5-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, and 4,5-dicaffeoylquinic acid in Xanthii Fructus from different producing areas were determined by HPLC method. The results were analyzed by PLS-DA and EW-TOPSIS method for excavate the main potential markers affecting the quality of Xanthii Fructus, and to evaluate qualities of Xanthii Fructus from different producing areas. Results The ten components had good linear relationships in their respective ranges. Chlorogenic acid, 1,5-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, carboxyatractyloside, and neochlorogenic acid were the main potential markers affecting the quality of Xanthii Fructus. The EW-TOPSIS method demonstrated that the qualities of Xanthii Fructus in Jiangsu and Shandong Province were the best. Conclusion The established HPLC method is convenient and accurate, and combined with PLS-DA and EW-TOPSIS method can be used for the comprehensive evaluation for quality of Xanthii Fructus.

R286.02

陕西省教育厅一般专项科研计划项目（21JK0590）