牙周炎是常见的口腔病变。抗生素治疗是牙周炎的常用治疗手段，但长期使用能引起不同程度的耐药性。丁香酚是从丁香中提取的有效成分，可通过抑菌作用、抗氧化作用、抗炎作用、调节巨噬细胞功能、阻止破骨细胞活化、镇痛作用、促骨再生作用等多种途径发挥防治牙周炎的作用。综述了丁香酚防治牙周炎的药理作用，为丁香酚在牙周炎的使用提供循证支持。

Periodontitis is the most common oral disease. Antibiotic therapy is a common treatment for periodontitis, but long-term use can cause different degrees of drug resistance. Eugenol is an active ingredient from Syzygium aromaticum, which can play a role in prevention and treatment of periodontitis by antibacterial effect, antioxidant effect, anti-inflammatory effect, regulating macrophage function, preventing osteoclast activation, analgesic effect, bone regeneration promotion effect. This paper reviews the pharmacological effects of eugenol in prevention and treatment of periodontitis, and provides evidence-based support for the application of eugenol in prevention and treatment of periodontitis.

R965

河北省卫生健康委医学科学研究课题计划（20171377）