目的 研究安儿宁颗粒联合头孢丙烯颗粒治疗小儿急性支气管炎的临床疗效。方法 选取2019年4月—2022年4月在南京医科大学第四附属医院门诊儿科治疗的86例急性支气管炎患儿，按照随机数字表法分为对照组和治疗组，每组各43例。对照组口服头孢丙烯颗粒，0.5g/次，2次/d。治疗组在对照组的治疗基础上口服安儿宁颗粒，6g/次，3次/d。两组患儿均连续治疗7d。观察两组的临床疗效，比较两组临床症状好转时间、白细胞（WBC）、中性粒细胞（NEUT）、淋巴细胞（LYM）、白细胞介素-6（IL-6）、超氧化物歧化酶（SOD）、肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）水平。结果 治疗后，治疗组总有效率是97.67%，显著高于对照组的79.07%（P<0.05）。治疗后，治疗组出现发热、咳嗽、头痛、肺部啰音等症状好转时间均显著短于对照组（P<0.05）。治疗后，两组血常规中WBC、LYM、NEUT指标均较治疗前显著降低（P<0.05）；治疗后，治疗组WBC、LYM、NEUT指标均低于对照组（P<0.05）。治疗后，两组血清因子IL-6、TNF-α、PCT水平均较治疗前显著降低，而SOD显著升高（P<0.05）；治疗后，治疗组血清因子水平改善均显著优于对照组（P<0.05）。治疗后，治疗组不良反应发生率是9.30%，显著低于对照组的16.28%（P<0.05）。结论 安儿宁颗粒联合头孢丙烯颗粒治疗小儿急性支气管炎具有较好的临床疗效，可明显改善临床症状，并降低炎性反应，具有一定的临床推广应用价值。

ObjectiveTo investigate the efficacy of An’erning Granules combined with cefprozil in treatment of acute bronchitis in children. Methods A total of 86 children with acute bronchitis treated in the outpatient department of the Fourth Affiliated Hospital of Nanjing Medical University from April 2019 to April 2022 were selected and divided into the control group and the treatment group according to the random number table method, with 43 cases in each group. Patients in the control group were po administered with Cefprozil Granules, 0.5 g/time, twice daily. Patients in the treatment group were po administered with An’erning Granules on the basis of the control group, 6 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the improvement time of clinical symptoms, white blood cell (WBC), neutrophil (NEUT), lymphocyte (LYM), interleukin-6 (IL-6), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), procalcitonin (PCT) levels were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 97.67%, which was significantly higher than that of the control group (79.07%, P < 0.05). After treatment, the improvement time of fever, cough, headache, pulmonary rales and other symptoms in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the WBC, LYM and NEUT indexes in blood routine of the two groups were significantly decreased compared with those before treatment (P< 0.05). After treatment, the WBC, LYM and NEUT indexes of the treatment group were lower than those of the control group (P < 0.05). After treatment, the serum levels of IL-6, TNF-α and PCT in the two groups were significantly decreased compared with those before treatment, but SOD was significantly increased (P < 0.05). After treatment, the improvement of serum factor levels in the treatment group was significantly better than that in the control group (P < 0.05). After treatment, the incidence of adverse reactions in the treatment group was 9.30%, which was significantly lower than 16.28% in the control group (P< 0.05). Conclusion An’erning Granules combined with cefprozil has a good clinical effect in treatment of acute bronchitis in children, and can significantly improve the clinical symptoms and reduce the inflammatory response, which has certain clinical application value.

R974